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HomeProduct name listnafiverine

nafiverine

  • CAS NO.:5061-22-3
  • Empirical Formula: C34H38N2O4
  • Molecular Weight: 538.684
  • MDL number: MFCD00865213
  • EINECS: 2257665
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
nafiverine  Structural

What is nafiverine ?

Originator

Naftidan,De Angeli,Italy,1969

Definition

ChEBI: Nafiverine is a member of naphthalenes.

Manufacturing Process

15 grams of α-methyl-1-naphthylacetic acid were refluxed with 50 ml of thionyl chloride during 3 hours. The excess thionyl chloride was removed under reduced pressure and the product was also isolated by distillation under reduced pressure. Yield: 15.6 grams (96%). The α-methyl-1-naphthyl acetyl chloride boils at 120° to 124°C. 1.76 grams of N,N'-di-(β-hydroxyethyl)- piperazine, 1.9 grams of sodium bicarbonate and 4.45 grams of α-methyl-1- naphthyl acetyl chloride in 30 ml of anhydrous acetonitrile were refluxed with stirring during 5 hours. After cooling the mixture was filtered and the acetonitrile evaporated off under reduced pressure. 5.2 grams of crude ester were obtained. The hydrochloride, melting at 220° to 221°C, may be prepared by dissolving the ester in absolute ethanol and treating the solution with anhydrous gaseous hydrogen chloride.

Therapeutic Function

Spasmolytic

Safety information for nafiverine

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