nafiverine
- CAS NO.：5061-22-3
- Empirical Formula: C34H38N2O4
- Molecular Weight: 538.684
- MDL number: MFCD00865213
- EINECS: 2257665
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:39
What is nafiverine ?
Originator
Naftidan,De Angeli,Italy,1969
Definition
ChEBI: Nafiverine is a member of naphthalenes.
Manufacturing Process
15 grams of α-methyl-1-naphthylacetic acid were refluxed with 50 ml of thionyl chloride during 3 hours. The excess thionyl chloride was removed under reduced pressure and the product was also isolated by distillation under reduced pressure. Yield: 15.6 grams (96%). The α-methyl-1-naphthyl acetyl chloride boils at 120° to 124°C. 1.76 grams of N,N'-di-(β-hydroxyethyl)- piperazine, 1.9 grams of sodium bicarbonate and 4.45 grams of α-methyl-1- naphthyl acetyl chloride in 30 ml of anhydrous acetonitrile were refluxed with stirring during 5 hours. After cooling the mixture was filtered and the acetonitrile evaporated off under reduced pressure. 5.2 grams of crude ester were obtained. The hydrochloride, melting at 220° to 221°C, may be prepared by dissolving the ester in absolute ethanol and treating the solution with anhydrous gaseous hydrogen chloride.
Therapeutic Function
Spasmolytic
Safety information for nafiverine
New Products
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![1-[2-(1-PROPYL)-OXYETHYL]-PIPERAZINE](https://img.chemicalbook.in/CAS/GIF/741667-07-2.gif)
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