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HomeProduct name listN3-PEG8-CH2CH2COOH

N3-PEG8-CH2CH2COOH

  • CAS NO.:1214319-92-2
  • Empirical Formula: C19H37N3O10
  • Molecular Weight: 467.51118
  • MDL number: MFCD21363300
  • Update Date: 2024-07-02 08:54:57
N3-PEG8-CH2CH2COOH Structural

What is N3-PEG8-CH2CH2COOH?

Description

Azido-PEG8-acid is a aqueous soluble PEG linker containing an azide (N3) and a terminal carboxylic acid (CO2H) group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

N3-PEG8-CH2CH2COOH is a non-cleavable ADC linker containing 8-unit PEG that can be used to synthesize antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.

Properties of N3-PEG8-CH2CH2COOH

storage temp.  -20°C
solubility  Soluble in Water, DMSO, DCM, DMF
form  solid or viscous liquid
color  Colorless to light yellow

Safety information for N3-PEG8-CH2CH2COOH

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P312:Call a POISON CENTER or doctor/physician if you feel unwell.
P321:Specific treatment (see … on this label).
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for N3-PEG8-CH2CH2COOH

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