N3-PEG8-CH2CH2COOH
- CAS NO.：1214319-92-2
- Empirical Formula: C19H37N3O10
- Molecular Weight: 467.51118
- MDL number: MFCD21363300
- Update Date: 2024-07-02 08:54:57
What is N3-PEG8-CH2CH2COOH?
Description
Azido-PEG8-acid is a aqueous soluble PEG linker containing an azide (N3) and a terminal carboxylic acid (CO2H) group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
N3-PEG8-CH2CH2COOH is a non-cleavable ADC linker containing 8-unit PEG that can be used to synthesize antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.
Properties of N3-PEG8-CH2CH2COOH
| storage temp. | -20°C |
| solubility | Soluble in Water, DMSO, DCM, DMF |
| form | solid or viscous liquid |
| color | Colorless to light yellow |
Safety information for N3-PEG8-CH2CH2COOH
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P321:Specific treatment (see … on this label). P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N3-PEG8-CH2CH2COOH
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