N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE

CAS NO.：18303-04-3
Empirical Formula: C12H17NO4S
Molecular Weight: 271.33
MDL number: MFCD00134267
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE?

The Uses of N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE

N-(tert-Butoxycarbonyl)-p-toluenesulfonamide may be used in the preparation of enyne amide, precursor for Pauson-Khand reaction.

What are the applications of Application

N-(tert-Butoxycarbonyl)-p-toluenesulfonamide is a chemical that affords sulfonyl-protected amines

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 379, 1994 DOI: 10.1016/0040-4039(94)85058-5

General Description

N-(tert-Butoxycarbonyl)-p-toluenesulfonamide is a N-substituted sulphonamide and its reaction with N-trityl L-serine esters under Mitsunobu reaction conditions is reported. It can be directly coupled with primary, secondary and allylic alcohols under Mitsunobu conditions to afford various sulfonyl-protected amines.

Properties of N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE

Melting point:	121-123 °C(lit.)
Density	1.201±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	chloroform: soluble25mg/mL, clear, colorless
form	powder to crystal
pka	4.84±0.10(Predicted)
color	White to Almost white
CAS DataBase Reference	18303-04-3

Safety information for N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.