N-(PHENYLTHIO)PHTHALIMIDE
- CAS NO.:14204-27-4
- Empirical Formula: C14H9NO2S
- Molecular Weight: 255.29
- MDL number: MFCD00192396
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is N-(PHENYLTHIO)PHTHALIMIDE?
Preparation
(a) Preparation of benzenesulfenyl chloride. To a stirred solution of 55 gm (0.5 mole) of benzene thiol in 300 ml of η -pentane at 0°C is added chlorine gas until an assay (GC) of the resulting red-orange solution shows quantitative conversion to the sulfenyl chloride. The reaction usually requires about 39 gm (0.6 mole) of chlorine.
(b) Reaction of benzenesulfenyl chloride with phthalimide. To a stirred solution of 73.5 gm (0.5 mole) of phthalimide in 200 ml of dimethylforma-mide is first added 60 gm (0.6 mole) of triethylamine. Then the sulfenyl chloride solution from (a) is slowly added dropwise. The reaction mixture is stirred for \ hr, poured into 2 liters of cold water, filtered, and dried to afford 121 gm (95%), m.p. 160-161°C (recrystallized from ethanol).
Complex imides such as camphorimide and 9,10-dihydroanthracene-9,10-endo-a,/3-succinimide have been alkylated in methylene dichloride with alkyl halides, using tetrabutylammonium bromide as a phase-transfer catalyst and aqueous potassium hydroxide as a base.
Properties of N-(PHENYLTHIO)PHTHALIMIDE
Melting point: | 160-163 °C(lit.) |
Boiling point: | 432.2±28.0 °C(Predicted) |
Density | 1.42±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO: soluble25mg/mL, clear, yellow |
form | powder to crystal |
pka | -3.05±0.20(Predicted) |
color | White to Light yellow |
CAS DataBase Reference | 14204-27-4 |
Safety information for N-(PHENYLTHIO)PHTHALIMIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-(PHENYLTHIO)PHTHALIMIDE
New Products
Tubulysin G Tubulysin D (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2,2-Difluoropropanol 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2H-Pyran, 4-ethynyltetrahydro- 3-Aminocyclobutanone hydrochloride 2,2-Difluoropropylamine hydrochloride Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH 4-(2-fluoro-4- nitrophenyl) thiomorpholine 4-N-Methylamino- 3-nitro benzoic acid Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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