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HomeProduct name listN-NITROSOMORPHOLINE

N-NITROSOMORPHOLINE

Synonym(s):NMOR

  • CAS NO.:59-89-2
  • Empirical Formula: C4H8N2O2
  • Molecular Weight: 116.12
  • MDL number: MFCD00039710
  • EINECS: 627-564-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-06 18:33:45
N-NITROSOMORPHOLINE Structural

What is N-NITROSOMORPHOLINE?

Chemical properties

yellow crystals or gold liquid

The Uses of N-NITROSOMORPHOLINE

N-Nitrosomorpholine, a frequently used genotoxic model carcinogen. Toxicogenomic analysis of N-Nitrosomorpholine induced changes in rat liver.

The Uses of N-NITROSOMORPHOLINE

Solvent for polyacrylonitrile; present during rubber manufacturing

What are the applications of Application

N-Nitrosomorpholine solution is a chemical used to study genotoxic carcinogen reactions as it induces carciinogen effects in vitro

Definition

ChEBI: A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.

Synthesis Reference(s)

Synthetic Communications, 22, p. 2607, 1992 DOI: 10.1080/00397919208021659

General Description

Yellow crystals. Golden liquid with many crystals at 68°F.

Air & Water Reactions

Water soluble.

Reactivity Profile

N-NITROSOMORPHOLINE is incompatible with strong oxidizing agents .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSOMORPHOLINE emits toxic fumes of nitrogen oxides.

Fire Hazard

Flash point data for N-NITROSOMORPHOLINE are not available; however, N-NITROSOMORPHOLINE is probably combustible.

Biochem/physiol Actions

Tumor initiator in rodent liver, trachea, nasal cavity, esophagus, kidney, lung, and thyroid.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Human mutation data reported. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Carcinogenicity

N-Nitrosomorpholine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Properties of N-NITROSOMORPHOLINE

Melting point: 29°C
Boiling point: 225℃
Density  1.2829 (rough estimate)
refractive index  1.4880 (estimate)
Flash point: 29 °C
storage temp.  2-8°C
Water Solubility  Completely soluble in water
solubility  DMSO : 100 mg/mL (861.18 mM)
form  neat
pka -5.72±0.20(Predicted)
form  <29°C Solid,>29°C Liquid
color  White or Colorless to Yellow
Merck  14,6640
Stability: Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents. Refrigerate, store in the dark.
IARC 2B (Vol. 17, Sup 7) 1987
EPA Substance Registry System N-Nitrosomorpholine (59-89-2)

Safety information for N-NITROSOMORPHOLINE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H301:Acute toxicity,oral
H351:Carcinogenicity
Precautionary Statement Codes P201:Obtain special instructions before use.

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