N-NITROSOMORPHOLINE
Synonym(s):NMOR
- CAS NO.:59-89-2
- Empirical Formula: C4H8N2O2
- Molecular Weight: 116.12
- MDL number: MFCD00039710
- EINECS: 627-564-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 18:33:45
What is N-NITROSOMORPHOLINE?
Chemical properties
yellow crystals or gold liquid
The Uses of N-NITROSOMORPHOLINE
N-Nitrosomorpholine, a frequently used genotoxic model carcinogen. Toxicogenomic analysis of N-Nitrosomorpholine induced changes in rat liver.
The Uses of N-NITROSOMORPHOLINE
Solvent for polyacrylonitrile; present during rubber manufacturing
What are the applications of Application
N-Nitrosomorpholine solution is a chemical used to study genotoxic carcinogen reactions as it induces carciinogen effects in vitro
Definition
ChEBI: A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.
Synthesis Reference(s)
Synthetic Communications, 22, p. 2607, 1992 DOI: 10.1080/00397919208021659
General Description
Yellow crystals. Golden liquid with many crystals at 68°F.
Air & Water Reactions
Water soluble.
Reactivity Profile
N-NITROSOMORPHOLINE is incompatible with strong oxidizing agents .
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSOMORPHOLINE emits toxic fumes of nitrogen oxides.
Fire Hazard
Flash point data for N-NITROSOMORPHOLINE are not available; however, N-NITROSOMORPHOLINE is probably combustible.
Biochem/physiol Actions
Tumor initiator in rodent liver, trachea, nasal cavity, esophagus, kidney, lung, and thyroid.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Human mutation data reported. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
Carcinogenicity
N-Nitrosomorpholine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Properties of N-NITROSOMORPHOLINE
Melting point: | 29°C |
Boiling point: | 225℃ |
Density | 1.2829 (rough estimate) |
refractive index | 1.4880 (estimate) |
Flash point: | 29 °C |
storage temp. | 2-8°C |
Water Solubility | Completely soluble in water |
solubility | DMSO : 100 mg/mL (861.18 mM) |
form | neat |
pka | -5.72±0.20(Predicted) |
form | <29°C Solid,>29°C Liquid |
color | White or Colorless to Yellow |
Merck | 14,6640 |
Stability: | Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents. Refrigerate, store in the dark. |
IARC | 2B (Vol. 17, Sup 7) 1987 |
EPA Substance Registry System | N-Nitrosomorpholine (59-89-2) |
Safety information for N-NITROSOMORPHOLINE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H301:Acute toxicity,oral H351:Carcinogenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. |
Computed Descriptors for N-NITROSOMORPHOLINE
Abamectin manufacturer
GLP Pharma Standards
DR MARK LABORATORIES PVT LTD
VIVAN Life Sciences Pvt Ltd
Molsyns Research
Orgamine Chemicals(I) Pvt Ltd
Clickchem Research LLP
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