N-(n-Nonyl)deoxynojirimycin
- CAS NO.:81117-35-3
- Empirical Formula: C15H31NO4
- Molecular Weight: 289.41
- MDL number: MFCD00905846
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:09
What is N-(n-Nonyl)deoxynojirimycin?
Chemical properties
White Crystalline Solid
The Uses of N-(n-Nonyl)deoxynojirimycin
An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. A possible therapeutic agent for Gaucher disease.
What are the applications of Application
N-(n-Nonyl)deoxynojirimycin is a glucosidase inhibitor
Definition
ChEBI: N-nonyldeoxynojirimycin is a hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group. It has a role as an EC 3.2.1.45 (glucosylceramidase) inhibitor, an EC 3.2.1.20 (alpha-glucosidase) inhibitor and an antiviral agent. It is a hydroxypiperidine and a tertiary amino compound. It is functionally related to a duvoglustat.
Biological Activity
Glucosidase inhibitor (IC 50 values are 0.42 and 8.4 μ M for acid α -glucosidase and α -1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo . Also acts as a chemical chaperone; chaperones β -Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.
Biochem/physiol Actions
NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.
storage
Store at -20°C
Properties of N-(n-Nonyl)deoxynojirimycin
Melting point: | 101-102°C |
Boiling point: | 451.7±45.0 °C(Predicted) |
Density | 1.112±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO: >10mg/mL |
form | solid |
pka | 13.72±0.70(Predicted) |
color | White to off-white |
Safety information for N-(n-Nonyl)deoxynojirimycin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-(n-Nonyl)deoxynojirimycin
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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