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HomeProduct name listN-(n-Nonyl)deoxynojirimycin

N-(n-Nonyl)deoxynojirimycin

N-(n-Nonyl)deoxynojirimycin Structural

What is N-(n-Nonyl)deoxynojirimycin?

Chemical properties

White Crystalline Solid

The Uses of N-(n-Nonyl)deoxynojirimycin

An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. A possible therapeutic agent for Gaucher disease.

What are the applications of Application

N-(n-Nonyl)deoxynojirimycin is a glucosidase inhibitor

Definition

ChEBI: N-nonyldeoxynojirimycin is a hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group. It has a role as an EC 3.2.1.45 (glucosylceramidase) inhibitor, an EC 3.2.1.20 (alpha-glucosidase) inhibitor and an antiviral agent. It is a hydroxypiperidine and a tertiary amino compound. It is functionally related to a duvoglustat.

Biological Activity

Glucosidase inhibitor (IC 50 values are 0.42 and 8.4 μ M for acid α -glucosidase and α -1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo . Also acts as a chemical chaperone; chaperones β -Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.

Biochem/physiol Actions

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.

storage

Store at -20°C

Properties of N-(n-Nonyl)deoxynojirimycin

Melting point: 101-102°C
Boiling point: 451.7±45.0 °C(Predicted)
Density  1.112±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO: >10mg/mL
form  solid
pka 13.72±0.70(Predicted)
color  White to off-white

Safety information for N-(n-Nonyl)deoxynojirimycin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for N-(n-Nonyl)deoxynojirimycin

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