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HomeProduct name listN-Methylleukotriene C4

N-Methylleukotriene C4

  • CAS NO.:131391-65-6
  • Empirical Formula: C31H49N3O9S
  • Molecular Weight: 639.81
  • MDL number: MFCD11113154
  • Update Date: 2024-10-28 23:16:16
N-Methylleukotriene C4 Structural

What is N-Methylleukotriene C4?

The Uses of N-Methylleukotriene C4

Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.

The Uses of N-Methylleukotriene C4

N-methyl Leukotriene C4 is synthetic analog of LTC4 with decreased binding affinity.

What are the applications of Application

N-methyl Leukotriene C4 is synthetic analog of LTC4 with decreased binding affinity

Properties of N-Methylleukotriene C4

Boiling point: 965.7±65.0 °C(Predicted)
Density  1.202±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; Ethanol:H20 (95:5): 2 mg/ml; PBS (pH 7.2): 100 μg/ml
pka 2.23±0.10(Predicted)

Safety information for N-Methylleukotriene C4

Computed Descriptors for N-Methylleukotriene C4

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