N-Methylleukotriene C4
- CAS NO.:131391-65-6
- Empirical Formula: C31H49N3O9S
- Molecular Weight: 639.81
- MDL number: MFCD11113154
- Update Date: 2023-06-08 09:03:09
What is N-Methylleukotriene C4?
The Uses of N-Methylleukotriene C4
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.
The Uses of N-Methylleukotriene C4
N-methyl Leukotriene C4 is synthetic analog of LTC4 with decreased binding affinity.
What are the applications of Application
N-methyl Leukotriene C4 is synthetic analog of LTC4 with decreased binding affinity
Properties of N-Methylleukotriene C4
Boiling point: | 965.7±65.0 °C(Predicted) |
Density | 1.202±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; Ethanol:H20 (95:5): 2 mg/ml; PBS (pH 7.2): 100 μg/ml |
pka | 2.23±0.10(Predicted) |
Safety information for N-Methylleukotriene C4
Computed Descriptors for N-Methylleukotriene C4
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