N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE
Synonym(s):Elastase Substrate I, Colorimetric - CAS 70967-90-7 - Calbiochem;Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide - CAS 70967-90-7 - Calbiochem;N-(Methoxysuccinyl)-L -alanyl-L -alanyl-L -prolyl-L -valine 4-nitroanilide;N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide
- CAS NO.：70967-90-7
- Empirical Formula: C27H38N6O9
- Molecular Weight: 590.63
- MDL number: MFCD00077137
- EINECS: 232-670-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:07
What is N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE?
Description
Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3, but not cathepsin G or chymotrypsin. Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm.
The Uses of N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE
N-Methoxysuccinyl-Ala-Ala-Pro-Val p-Nitroanilide is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3 but not cathespin.
What are the applications of Application
MeOSuc-AAPV-pNA, Chromogenic Substrate is a sensitive PR3 and neutrophil elastase chromogenic substrate
Properties of N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE
| Melting point: | 203-205°C |
| Boiling point: | 958.4±65.0 °C(Predicted) |
| Density | 1.297±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 25 mg/mL, clear, light yellow |
| form | Off-white solid |
| pka | 13.29±0.20(Predicted) |
| color | White to Off-White |
| BRN | 6266359 |
Safety information for N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE
Computed Descriptors for N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE
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