Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listN-Desmethyl Imatinib

N-Desmethyl Imatinib

  • CAS NO.:404844-02-6
  • Empirical Formula: C28H29N7O
  • Molecular Weight: 479.58
  • MDL number: MFCD07369291
  • EINECS: 1592732-453-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
N-Desmethyl Imatinib Structural

What is N-Desmethyl Imatinib?

Description

N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.

Chemical properties

Off-White to Pale-Yellow Solid

The Uses of N-Desmethyl Imatinib

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

The Uses of N-Desmethyl Imatinib

aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes

The Uses of N-Desmethyl Imatinib

anti-epileptic

What are the applications of Application

N-Desmethyl Imatinib is a metabolite of Imatinib

Definition

ChEBI: N-Demethylated piperazine is a member of benzamides.

Properties of N-Desmethyl Imatinib

Melting point: 99-101°C
Density  1.268±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml
form  A lyophilized solid
pka 13.28±0.70(Predicted)
color  Light yellow to yellow

Safety information for N-Desmethyl Imatinib

Computed Descriptors for N-Desmethyl Imatinib

Related products of tetrahydrofuran

You may like

  • 404844-02-6 N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-(piperazin-1-ylmethyl)benzamide 98%
    404844-02-6 N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-(piperazin-1-ylmethyl)benzamide 98%
    404844-02-6
    View Details
  • 404844-02-6 98%
    404844-02-6 98%
    404844-02-6
    View Details
  • Imatinib Impurity C 98%
    Imatinib Impurity C 98%
    404844-02-6
    View Details
  • Imatinib Impurity C (Imatinib (Piperidine)-N4- Oxide) 404844-02-6 98%
    Imatinib Impurity C (Imatinib (Piperidine)-N4- Oxide) 404844-02-6 98%
    404844-02-6
    View Details
  • 404844-02-6 N-(4-Methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino) phenyl)-4- (piperazin-1-ylmethyl)benzamide 99%
    404844-02-6 N-(4-Methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino) phenyl)-4- (piperazin-1-ylmethyl)benzamide 99%
    404844-02-6
    View Details
  • Imatinib EP Impurity C (N-Desmethyl Imatinib) 98% (HPLC) CAS 404844-02-6
    Imatinib EP Impurity C (N-Desmethyl Imatinib) 98% (HPLC) CAS 404844-02-6
    404844-02-6
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.