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HomeProduct name listN-Desmethyl Imatinib

N-Desmethyl Imatinib

  • CAS NO.:404844-02-6
  • Empirical Formula: C28H29N7O
  • Molecular Weight: 479.58
  • MDL number: MFCD07369291
  • EINECS: 1592732-453-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-01 13:17:44
N-Desmethyl Imatinib Structural

What is N-Desmethyl Imatinib?

Description

N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.

Chemical properties

Off-White to Pale-Yellow Solid

The Uses of N-Desmethyl Imatinib

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

The Uses of N-Desmethyl Imatinib

aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes

The Uses of N-Desmethyl Imatinib

anti-epileptic

What are the applications of Application

N-Desmethyl Imatinib is a metabolite of Imatinib

Definition

ChEBI: N-Demethylated piperazine is a member of benzamides.

Properties of N-Desmethyl Imatinib

Melting point: 99-101°C
Density  1.268±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml
form  A lyophilized solid
pka 13.28±0.70(Predicted)
color  Light yellow to yellow

Safety information for N-Desmethyl Imatinib

Computed Descriptors for N-Desmethyl Imatinib

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