N-Desmethyl Imatinib
- CAS NO.:404844-02-6
- Empirical Formula: C28H29N7O
- Molecular Weight: 479.58
- MDL number: MFCD07369291
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:07
What is N-Desmethyl Imatinib?
Description
N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.
Chemical properties
Off-White to Pale-Yellow Solid
The Uses of N-Desmethyl Imatinib
N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
The Uses of N-Desmethyl Imatinib
aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes
The Uses of N-Desmethyl Imatinib
anti-epileptic
What are the applications of Application
N-Desmethyl Imatinib is a metabolite of Imatinib
Definition
ChEBI: N-Demethylated piperazine is a member of benzamides.
Properties of N-Desmethyl Imatinib
Melting point: | 99-101°C |
Density | 1.268±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml |
form | A lyophilized solid |
pka | 13.28±0.70(Predicted) |
color | Light yellow to yellow |
Safety information for N-Desmethyl Imatinib
Computed Descriptors for N-Desmethyl Imatinib
Abamectin manufacturer
Glyra Health Care Pvt Ltd
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