1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
- CAS NO.：55314-16-4
- Empirical Formula: C10H12N2O
- Molecular Weight: 176.22
- MDL number: MFCD00115180
- EINECS: 611-255-8;434-770-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-18 21:58:05
What is 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one?
Description
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours.
Chemical properties
Off-White Solid
The Uses of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
Imatinib intermediate
The Uses of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
Rasagiline intermediate
The Uses of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate.
What are the applications of Application
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is an imatinib intermediate
Solubility in organics
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane.
Properties of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
| Melting point: | 86-88 |
| Boiling point: | 281.4±36.0 °C(Predicted) |
| Density | 1.070±0.06 g/cm3(Predicted) |
| vapor pressure | 0.049Pa at 20℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in chloroform and dichloromethane. |
| form | powder to crystal |
| pka | 6.19±0.70(Predicted) |
| color | Light yellow to Brown |
| CAS DataBase Reference | 55314-16-4(CAS DataBase Reference) |
Safety information for 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
| InChIKey | MZLRFUCMBQWLNV-FNORWQNLSA-N |
Abamectin manufacturer
Lorven therapeutics Pvt Ltd
1Y
Phone:+91-8884110005
Whatsapp: +91 8884110005
product: 3-(Dimethylamino)-1-(Pyridin-3-yl) Prop-2-En-1-one 55314-16-4 98%
Varanous Labs Pvt Ltd
1Y
Phone:+917036248882
Whatsapp: +91 7036248882
product: 55314-16-4 Imatinib Impurity A 98%
Everest Organics Limited
1Y
Phone:+91-9440409996
Whatsapp: +91-9440409996
product: 55314-16-4 / 123367-26-0 99%
Vasoya Industries Pvt Ltd
1Y
Phone:+91-9898083583
Whatsapp: +91-9898083583
product: 3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one 99%
Riddhesh Pharmachem
1Y
Phone:+91-9106014993
Whatsapp: +91 9324548771
product: 3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one 55314-16-4 / 123367-26-0 98%
ALS INDIA LIFE SCIENCES
1Y
Phone:+91-8977036379
Whatsapp: +91 8008166674
product: 55314-16-4 / 123367-26-0 3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one 98%
Medicina Lyfe Care
1Y
Phone:+91-9687603963
Whatsapp: +91-9687603963
product: 55314-16-4 / 123367-26-0 98%
New Products
(R)-(-)-2-Amino-1-propanol Tetrahydro-4H-pyran-4-one Bromine 99.5% AR (4 x 500ml) Linseed Oil Extrapure Hydrogen Sulphide Solution Oxalic Acid 0.05 mol/L (0.01N) Solution EDTA 0.1 mol/L (0.2N) for 1000 ml Ferroin 0.025M Solution AR 1,2,3,4-Tetrahydrocarbazol-4-one 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid Acetone Isobutryl oxime ester Sodium Amino Salicylate Dihydrate (PAS Sodium) IP/BP/USP/EP Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Spirulina (Arthrospira platensis) Powder Trikatu Extract Thymol Oil Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride 5-NitrosalicylaldehydeRelated products of tetrahydrofuran
![1-(4,6-dibroMo-3-fluorothieno[3,4-b]thiophen-2-yl)-2ethylhexan-1-one](https://img.chemicalbook.in/CAS/20150408/GIF/1352743-83-9.gif)
![1-(4,6-dibromothieno[3,4-b]thiophen-2-yl)-2-ethylhexan-1-one](https://img.chemicalbook.in/CAS/GIF/1194605-76-9.gif)
![1-[2-[BIS(TERT-BUTYL)PHOSPHINO]PHENYL]-3,5-DIPHENYL-1H-PYRAZOLE](https://img.chemicalbook.in/CAS/GIF/628333-86-8.gif)
![4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide](https://img.chemicalbook.in/CAS/GIF/404844-11-7.gif)
You may like
-
55314-16-4 3-(Dimethylamino)-1-(Pyridin-3-yl) Prop-2-En-1-One 98%View Details
55314-16-4 -
55314-16-4 99%View Details
55314-16-4 -
3-(Dimethylamino)-1-(Pyridin-3-yl) Prop-2-En-1-one 55314-16-4 98%View Details
55314-16-4 -
55314-16-4 Imatinib Impurity A 98%View Details
55314-16-4 -
55314-16-4 / 123367-26-0 99%View Details
55314-16-4 / 123367-26-0 -
3-(dimethyl amino)-1-(3-pyridinyl)-2-propen-1-one 99%View Details
55314-16-4 -
55314-16-4 / 123367-26-0 3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one 98%View Details
55314-16-4 / 123367-26-0 -
(2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one CASView Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.