1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
- CAS NO.：55314-16-4
- Empirical Formula: C10H12N2O
- Molecular Weight: 176.22
- MDL number: MFCD00115180
- EINECS: 611-255-8;434-770-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one?
Description
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours.
Chemical properties
Off-White Solid
The Uses of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
Imatinib intermediate
The Uses of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
Rasagiline intermediate
The Uses of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate.
What are the applications of Application
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is an imatinib intermediate
Solubility in organics
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane.
Properties of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
| Melting point: | 86-88 |
| Boiling point: | 281.4±36.0 °C(Predicted) |
| Density | 1.070±0.06 g/cm3(Predicted) |
| vapor pressure | 0.049Pa at 20℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in chloroform and dichloromethane. |
| form | powder to crystal |
| pka | 6.19±0.70(Predicted) |
| color | Light yellow to Brown |
| CAS DataBase Reference | 55314-16-4(CAS DataBase Reference) |
Safety information for 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
| InChIKey | MZLRFUCMBQWLNV-FNORWQNLSA-N |
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one manufacturer
New Products
Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2,2-Difluoropropylamine hydrochloride tert-butyl 3-bromoazetidine-1-carboxylate (R)-1-Boc-3-hydroxypyrrolidine DIFLUOROACETIC ANHYDRIDE 2,2-Difluoropropionic acid Diallylamine, 99% Calcium hydroxide, 95% Aluminum oxide, basic 2-Bromophenylacetonitrile, 97% L-tert-Leucine,97% N-Hydroxy-2-methylpropanimidamide 4-(3,4-Dichlorophenyl)-3,4-Dihydro-N-Methyl-1-(2H)-Naphthalenimine (Schiff Base) 2-AMINO-3,5-DIBROMO BENZALDEHYDE [ADBA] L-Glutamic Acid Dimethyl Ester Hcl 10-Methoxy-5H-dibenz[b,f]azepine 5-Cyanophthalide N, N-Carbonyldiimidazole (CDI) Dibenzoyl Peroxide Titanium Dioxide 2-(Methylthio) Benzonitrile Sodium Acetate Anhydrous Allopurinol 1,5-DibromopentaneRelated products of tetrahydrofuran
![1-(4,6-dibroMo-3-fluorothieno[3,4-b]thiophen-2-yl)-2ethylhexan-1-one](https://img.chemicalbook.in/CAS/20150408/GIF/1352743-83-9.gif)
![1-(4,6-dibromothieno[3,4-b]thiophen-2-yl)-2-ethylhexan-1-one](https://img.chemicalbook.in/CAS/GIF/1194605-76-9.gif)
![1-[2-[BIS(TERT-BUTYL)PHOSPHINO]PHENYL]-3,5-DIPHENYL-1H-PYRAZOLE](https://img.chemicalbook.in/CAS/GIF/628333-86-8.gif)
![4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide](https://img.chemicalbook.in/CAS/GIF/404844-11-7.gif)
You may like
-
55314-16-4 3-(Dimethylamino)-1-(Pyridin-3-yl) Prop-2-En-1-One 98%View Details
55314-16-4 -
55314-16-4 99%View Details
55314-16-4 -
55314-16-4 Imatinib Impurity A 98%View Details
55314-16-4 -
55314-16-4 / 123367-26-0 99%View Details
55314-16-4 / 123367-26-0 -
3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one 55314-16-4 / 123367-26-0 98%View Details
55314-16-4 / 123367-26-0 -
3-(dimethyl amino)-1-(3-pyridinyl)-2-propen-1-one 99%View Details
55314-16-4 -
55314-16-4 / 123367-26-0 3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one 98%View Details
55314-16-4 / 123367-26-0 -
(2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one CASView Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.