1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
- CAS NO.：55314-16-4
- Empirical Formula: C10H12N2O
- Molecular Weight: 176.22
- MDL number: MFCD00115180
- EINECS: 611-255-8;434-770-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-27 11:01:09
What is 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one?
Description
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours.
Chemical properties
Off-White Solid
The Uses of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
Imatinib intermediate
The Uses of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
Rasagiline intermediate
The Uses of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate.
What are the applications of Application
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is an imatinib intermediate
Solubility in organics
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane.
Properties of 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
| Melting point: | 86-88 |
| Boiling point: | 281.4±36.0 °C(Predicted) |
| Density | 1.070±0.06 g/cm3(Predicted) |
| vapor pressure | 0.049Pa at 20℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in chloroform and dichloromethane. |
| form | powder to crystal |
| pka | 6.19±0.70(Predicted) |
| color | Light yellow to Brown |
| CAS DataBase Reference | 55314-16-4(CAS DataBase Reference) |
Safety information for 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
| InChIKey | MZLRFUCMBQWLNV-FNORWQNLSA-N |
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one manufacturer
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