Boc-D-Ser(Bzl)-OH
Synonym(s):Boc-Ser(Bzl)-OH;N-α-t.-Boc-O-benzyl-D-serine;N-α-t.-Boc-O-benzyl-L-serine;Boc-O-benzyl-D -serine;Boc-O-benzyl-L -serine
- CAS NO.:47173-80-8
- Empirical Formula: C15H21NO5
- Molecular Weight: 295.33
- MDL number: MFCD00038248
- EINECS: 827-299-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-16 10:38:43
What is Boc-D-Ser(Bzl)-OH?
Chemical properties
White crystalline powder
The Uses of Boc-D-Ser(Bzl)-OH
N-BOC-O-Benzyl-D-serine, is an amino acid derivative used in chemical synthesis and peptide chemistry.is used in preparation of substituted naphthyl thiadiazolidinones as protein tyrosine phosphatase degraders for treating cancer and metabolic diseases.
Biological Activity
Boc-O-benzyl-D-serine is an inhibitor of the uptake of galactose and its derivatives. It has potent inhibitory activity against the uptake of galactose, glucose, and lactose. This drug is also effective in inhibiting the uptake of tetrazole, a substance that inhibits glycolysis. Boc-O-benzyl-D-serine is able to inhibit atherosclerotic lesions caused by piperidine, which has been shown to be synthesized from benzyl alcohol and piperidine. The oral administration of this compound can enhance fibroblast cells that are resistant to insulin.
Synthesis
N-Boc D-Se (500 mg, 2.43 mmol) dissolved in anhydrous DMF (4 mL) was slowly added to a dispersion of 60% NaH (204 mg, 5.1 mmol) in anhydrous DMF at 0 ° C. Stir the mixture at room temperature for 1 hour and cool to 0 ° C. Subsequently, benzyl bromide (0.29 mL, 2.43 mmol) was added and the mixture was heated to room temperature. After 4 hours of reaction, add saturated NH4Cl (1 mL) to quench the reaction. Finally, the product Boc-D-Ser(Bzl)-OH was obtained through purification.
Properties of Boc-D-Ser(Bzl)-OH
Melting point: | 58-60 °C(lit.) |
Boiling point: | 437.02°C (rough estimate) |
alpha | -19 º (c=2 80% alcohol) |
Density | 1.1454 (rough estimate) |
refractive index | -20 ° (C=2, 80% EtOH) |
storage temp. | Sealed in dry,Room Temperature |
solubility | almost transparency in Methanol |
form | Powder |
pka | 3.53±0.10(Predicted) |
color | White |
BRN | 2665080 |
InChI | InChI=1S/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)10-20-9-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,19)(H,17,18)/t12-/m1/s1 |
CAS DataBase Reference | 47173-80-8(CAS DataBase Reference) |
Safety information for Boc-D-Ser(Bzl)-OH
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Boc-D-Ser(Bzl)-OH
InChIKey | DMBKPDOAQVGTST-GFCCVEGCSA-N |
SMILES | C(O)(=O)[C@@H](COCC1=CC=CC=C1)NC(OC(C)(C)C)=O |
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