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HomeProduct name listBoc-D-Ser(Bzl)-OH

Boc-D-Ser(Bzl)-OH

Synonym(s):Boc-Ser(Bzl)-OH;N-α-t.-Boc-O-benzyl-D-serine;N-α-t.-Boc-O-benzyl-L-serine;Boc-O-benzyl-D-serine;Boc-O-benzyl-L-serine

  • CAS NO.:47173-80-8
  • Empirical Formula: C15H21NO5
  • Molecular Weight: 295.33
  • MDL number: MFCD00038248
  • EINECS: 827-299-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-16 10:38:43
Boc-D-Ser(Bzl)-OH Structural

What is Boc-D-Ser(Bzl)-OH?

Chemical properties

White crystalline powder

The Uses of Boc-D-Ser(Bzl)-OH

N-BOC-O-Benzyl-D-serine, is an amino acid derivative used in chemical synthesis and peptide chemistry.is used in preparation of substituted naphthyl thiadiazolidinones as protein tyrosine phosphatase degraders for treating cancer and metabolic diseases.

Biological Activity

Boc-O-benzyl-D-serine is an inhibitor of the uptake of galactose and its derivatives. It has potent inhibitory activity against the uptake of galactose, glucose, and lactose. This drug is also effective in inhibiting the uptake of tetrazole, a substance that inhibits glycolysis. Boc-O-benzyl-D-serine is able to inhibit atherosclerotic lesions caused by piperidine, which has been shown to be synthesized from benzyl alcohol and piperidine. The oral administration of this compound can enhance fibroblast cells that are resistant to insulin.

Synthesis

N-Boc D-Se (500 mg, 2.43 mmol) dissolved in anhydrous DMF (4 mL) was slowly added to a dispersion of 60% NaH (204 mg, 5.1 mmol) in anhydrous DMF at 0 ° C. Stir the mixture at room temperature for 1 hour and cool to 0 ° C. Subsequently, benzyl bromide (0.29 mL, 2.43 mmol) was added and the mixture was heated to room temperature. After 4 hours of reaction, add saturated NH4Cl (1 mL) to quench the reaction. Finally, the product Boc-D-Ser(Bzl)-OH was obtained through purification.

Properties of Boc-D-Ser(Bzl)-OH

Melting point: 58-60 °C(lit.)
Boiling point: 437.02°C (rough estimate)
alpha  -19 º (c=2 80% alcohol)
Density  1.1454 (rough estimate)
refractive index  -20 ° (C=2, 80% EtOH)
storage temp.  Sealed in dry,Room Temperature
solubility  almost transparency in Methanol
form  Powder
pka 3.53±0.10(Predicted)
color  White
BRN  2665080
InChI InChI=1S/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)10-20-9-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,19)(H,17,18)/t12-/m1/s1
CAS DataBase Reference 47173-80-8(CAS DataBase Reference)

Safety information for Boc-D-Ser(Bzl)-OH

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Boc-D-Ser(Bzl)-OH

InChIKey DMBKPDOAQVGTST-GFCCVEGCSA-N
SMILES C(O)(=O)[C@@H](COCC1=CC=CC=C1)NC(OC(C)(C)C)=O

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