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HomeProduct name listDMT-2'O-TBDMS-rA(bz) Phosphoramidite

DMT-2'O-TBDMS-rA(bz) Phosphoramidite

Synonym(s):DMT-2’O-TBDMS-rA(bz) Amidite;N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-adenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

  • CAS NO.:104992-55-4
  • Empirical Formula: C53H66N7O8PSi
  • Molecular Weight: 988.19
  • MDL number: MFCD00080297
  • EINECS: 2017-001-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-12-13 09:26:12
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Structural

What is DMT-2'O-TBDMS-rA(bz) Phosphoramidite?

The Uses of DMT-2'O-TBDMS-rA(bz) Phosphoramidite

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.

The Uses of DMT-2'O-TBDMS-rA(bz) Phosphoramidite

DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.

Synthesis

Synthesis_104992-55-4
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)

Properties of DMT-2'O-TBDMS-rA(bz) Phosphoramidite

storage temp.  Inert atmosphere,Store in freezer, under -20°C
form  powder
pka 7.87±0.43(Predicted)
color  white to off-white

Safety information for DMT-2'O-TBDMS-rA(bz) Phosphoramidite

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for DMT-2'O-TBDMS-rA(bz) Phosphoramidite

InChIKey FFXHNCNNHASXCT-RFMFGJHUSA-N

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