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HomeProduct name listBoc-Lys-OH

Boc-Lys-OH

Synonym(s):Nα-(tert-Butoxycarbonyl)-L-lysine;Nα-Boc-L-lysine;Boc-Lys-OH;N-α-t.-Boc-L-lysine

  • CAS NO.:13734-28-6
  • Empirical Formula: C11H22N2O4
  • Molecular Weight: 246.3
  • MDL number: MFCD00038203
  • EINECS: 237-303-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
Boc-Lys-OH Structural

What is Boc-Lys-OH?

Chemical properties

white to off-white powder

The Uses of Boc-Lys-OH

N-Boc-L-lysine is a protected analogue of a major amino acid participating in the binding of AcH to proteins. N-Boc-L-lysine as well as other t-butoxycarbonyl (Boc) amino acids can be converted to their respective amino acids via cleavage of the urethane bond.

The Uses of Boc-Lys-OH

Boc-Lys-OH (Nα-Boc-L-lysine) can be used as a building block to synthesize:
A heterotrifunctional peptide-based linker molecule applicable as a bio-labeling reagent.
Lysine derivatives of azamacrocycle and anthraquinone.
Boc-Lys(Bn4-DTPA)-OH, a precursor to synthesize diethylene triamine pentaacetic acid (DTPA) containing peptides.
A ferrocene-amino acid conjugate which is used in developing chemical warfare agent (CWA) sensor.

The Uses of Boc-Lys-OH

N-Boc-L-lysine is a protected analogue of a major amino acid participating in the binding of AcH to proteins. N-Boc-L-lysine as well as other t-butoxycarbonyl (Boc) amino acids can be converted to the ir respective amino acids via cleavage of the urethane bond.

What are the applications of Application

Boc-Lys-OH is an N-Boc protected lysine derivative

Production Methods

L-lysine was added to acetone and Et3N under stirring at 25 °C. After that, di-tert-butyl dicarbonate was added. After 4.5 h, decompression evaporates acetone, and the water layer is extracted with ethyl ether 3 times. The dilute HC1 was added to the aqueous layer to adjust pH 2-3. The crude product was purified to obtain Boc-Lys-OH.
N-alpha-(tert-Butoxycarbonyl)-L-lysine

reaction suitability

Boc solid-phase peptide synthesis

Properties of Boc-Lys-OH

Melting point: ~205 °C (dec.)(lit.)
Boiling point: 389.3°C (rough estimate)
alpha  22 º (c=2, CH3OH)
Density  1.1313 (rough estimate)
refractive index  21.5 ° (C=2, MeOH)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Acetic Acid (Slightly), Methanol (Slightly, Sonicated), Water (Slightly, Heated,
form  Powder
pka 3.92±0.21(Predicted)
color  White
optical activity [α]20/D +4.6±0.5°, c = 2% in H2O
Water Solubility  Soluble in water. Slightly soluble in methanol.
BRN  4252546
InChI InChI=1S/C11H22N2O4/c1-11(2,3)17-10(16)13-8(9(14)15)6-4-5-7-12/h8H,4-7,12H2,1-3H3,(H,13,16)(H,14,15)/t8-/m0/s1
CAS DataBase Reference 13734-28-6(CAS DataBase Reference)

Safety information for Boc-Lys-OH

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for Boc-Lys-OH

InChIKey DQUHYEDEGRNAFO-QMMMGPOBSA-N
SMILES C(O)(=O)[C@H](CCCCN)NC(OC(C)(C)C)=O

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