Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listBOC-L-Proline

BOC-L-Proline

Synonym(s):N-(tert-Butoxycarbonyl)-L-proline;Boc-L-proline;Boc-Pro-OH;N-α-t.-Boc-L-proline

  • CAS NO.:15761-39-4
  • Empirical Formula: C10H17NO4
  • Molecular Weight: 215.25
  • MDL number: MFCD00037324
  • EINECS: 239-848-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-06-04 19:18:49
BOC-L-Proline Structural

What is BOC-L-Proline?

Description

N-Boc-L-proline is a synthetic intermediate. It has been used in the synthesis of enantioselective catalysts for aldol reactions and hepatitis C virus (HCV) NS5A inhibitors.

Chemical properties

White to off-white microcrystalline powder

The Uses of BOC-L-Proline

N-Boc-L-proline is used as an intermediate in organic synthesis. It is also used to prepare daclatasvir, which inhibits the hepatitis C virus (HCV) non-structural 5A (NS5A) protein. Further, it is used as a drug in the treatment of hepatitis C virus (HCV).

What are the applications of Application

Boc-Pro-OH is a useful synthetic intermediate

Preparation

Triethylamine (16.5 mL, 0.12 mmol) was added dropwise over a period of 10 min to a stirred, ice-cold suspension of l-proline (10.0 g, 8.7 mmol) in dichloromethane (200 mL) in a 500-mL three-necked, round-bottomed flask. A solution of Boc2O (28.3 g, 0.13 mmol) in dichloromethane (100 mL) was then added over a period of 10 min and the mixture was stirred for 2.5 h. Thereafter, 10% aqueous citric acid (50 mL) was added, and the dichloromethane layer was washed with saturated brine (2×50 mL) and with water (50 mL). After drying the organic phase over magnesium sulfate, the solvent was evaporated and the residue was taken up in hot ethyl acetate. Dilution of this solution with hexane gave the product, N-tertbutoxycarbonyl- L-proline (17.8 g, 95%); mp 138–140℃; TLC (silica gel): Rf=0:36 (EtOAc/MeOH, 1:1).

Properties of BOC-L-Proline

Melting point: 133-135 °C(lit.)
Boiling point: 355.52°C (rough estimate)
alpha  -60.5 º (c=1, HAc)
Density  1.1835 (rough estimate)
refractive index  -60 ° (C=2, AcOH)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Soluble in acetic acid.
form  Crystals or Crystalline Powder
pka 4.01±0.20(Predicted)
color  White
optical activity [α]20/D 61±2°, c = 2% in acetic acid
BRN  15828
CAS DataBase Reference 15761-39-4(CAS DataBase Reference)
EPA Substance Registry System 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- (15761-39-4)

Safety information for BOC-L-Proline

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for BOC-L-Proline

InChIKey ZQEBQGAAWMOMAI-ZETCQYMHSA-N

Abamectin manufacturer

TEADUS PHARMA PRIVATE LIMITED

1Y
Phone:+919740077663
Whatsapp: +91 9740077663
product: 15761-39-4 95%
Inquiry

SV CHEM INTERMEDITES PRIVATE LIMITED

1Y
Phone:+919940629423
Whatsapp: +91 9940629423
product: BOC-L-Proline 99%
Inquiry

JSK Chemicals

1Y
Phone:+919879767970
Whatsapp: +91 9879767970
product: N-Boc-L-proline, 95% 15761-39-4 99%
Inquiry

Noble Molecular Research

1Y
Phone:+91-9717706044
Whatsapp: +91 9717706044
product: 15761-39-4 N-tert-Butoxycarbonyl-L-proline 99%
Inquiry

Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
Phone:+91-7926462688
product: 15761-39-4 98%
Inquiry

ALS INDIA LIFE SCIENCES

1Y
Phone:+91-8977036379
Whatsapp: +91 8008166674
product: N-tert-Butoxycarbonyl-L-proline 98%
Inquiry

Atul Bioscience Ltd

1Y
Phone:+91-9316723499
Whatsapp: +91 9316723499
product: N-tert-Butoxycarbonyl-L-proline 15761-39-4 99%
Inquiry

Arnavi Laboratory

1Y
Phone:+91-7780703633
Whatsapp: +91-7780703633
product: 15761-39-4 N-tert-Butoxycarbonyl-L-proline 98%
Inquiry

Aurazia Chem Laboratories Private Limited

1Y
Phone:+91-8754492844
Whatsapp: +91-8754492844
product: 15761-39-4 98%
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.