N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
- CAS NO.:261766-23-8
- Empirical Formula: C27H24ClN3O4
- Molecular Weight: 489.95
- MDL number: MFCD02683236
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:03
What is N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE?
Description
N-
Chemical properties
Pale Yellow Solid
The Uses of N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively
What are the applications of Application
N-(4-Acetamidophenyl)indomethacin Amide is a selective reversible Cox-2 inhibitor
Definition
ChEBI: N-(4-acetamidophenyl)-Indomethacin amide is a N-acylindole.
References
[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.
Properties of N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
Melting point: | 256-257°C |
storage temp. | −20°C |
solubility | DMSO: ≥15 mg/mL |
form | crystalline |
color | Pale Yellow |
Safety information for N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
Computed Descriptors for N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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