5-METHOXY-2-METHYLINDOLE
Synonym(s):NSC 63817
- CAS NO.:1076-74-0
- Empirical Formula: C10H11NO
- Molecular Weight: 161.2
- MDL number: MFCD00005620
- EINECS: 214-066-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-07 20:48:41
What is 5-METHOXY-2-METHYLINDOLE?
Description
5-methoxy-2-methylindole is a useful organic raw material. It can be used as the reactant in the preparation of indolylquinoxalines by condensation reactions, in preparation of alkylindoles via Ir-catalyzed reductive alkylation, in arylation reactions in the presence of a palladium acetate catalyst, in enantioselective Friedel-Crafts alkylation, as well as in stereo selective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. It is also employed in inhibiting the chlorinating activity of myeloperoxidase (MPO) and in the metabolic synthesis of acrylacetic acid anti-inflammatory synthesis.
Chemical properties
white to light beige crystalline powder or
The Uses of 5-METHOXY-2-METHYLINDOLE
An indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid antiinflammatory synthesis.
The Uses of 5-METHOXY-2-METHYLINDOLE
reactant in preparation of indolylquinoxalines by condensation reactions1reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation2reactant in arylation reactions using a palladium acetate catalyst3reactant in enantioselective Friedel-Crafts alkylation4reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation5
The Uses of 5-METHOXY-2-METHYLINDOLE
It is employed as a reactant in preparation of indolylquinoxalines by condensation reactions, reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation, reactant in arylation reactions using a palladium acetate catalyst, reactant in enantioselective Friedel-Crafts alkylation and reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. As an indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid anti-inflammatory synthesis.
Definition
ChEBI: 5-Methoxy-2-methyl-1H-indole is a member of indoles.
References
https://www.alfa.com/en/catalog/B21348/
http://www.sigmaaldrich.com/catalog/product/aldrich/m15451?lang=en®ion=US
https://pubchem.ncbi.nlm.nih.gov/compound/5-Methoxy-2-methylindole#section=2D-Structure
Properties of 5-METHOXY-2-METHYLINDOLE
Melting point: | 86-88 °C (lit.) |
Boiling point: | 145 °C / 1.5mmHg |
Density | 1.0840 (rough estimate) |
refractive index | 1.5200 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Soluble in methanol (very faint turbidity.) |
form | Crystalline Powder or Crystals |
pka | 17.28±0.30(Predicted) |
color | White to light beige |
CAS DataBase Reference | 1076-74-0(CAS DataBase Reference) |
Safety information for 5-METHOXY-2-METHYLINDOLE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-METHOXY-2-METHYLINDOLE
InChIKey | VSWGLJOQFUMFOQ-UHFFFAOYSA-N |
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