N-(3-Trifluoromethylphenyl)piperazine

CAS NO.：15532-75-9
Empirical Formula: C11H13F3N2
Molecular Weight: 230.23
MDL number: MFCD00005959
EINECS: 239-574-4
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is N-(3-Trifluoromethylphenyl)piperazine?

Chemical properties

clear colourless to yellow slightly viscous liquid

The Uses of N-(3-Trifluoromethylphenyl)piperazine

1-[3-(Trifluoromethyl)phenyl]piperazine is used in preparation of (Piperazinylethyl)cyclohexanamide derivatives and used as treatment or prevention of D3 and/or 5HT-2 receptor diseases.

Definition

ChEBI: A N-arylpiperazine that is piperazine substituted by a 3-(trifluoromethyl)phenyl group at position 1. A serotonergic agonist used as a recreational drug.

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 319, 1996 DOI: 10.1016/0040-4039(95)02162-0

Properties of N-(3-Trifluoromethylphenyl)piperazine

Boiling point:	100-102°C 0,1mm
Density	1.226 g/mL at 25 °C(lit.)
refractive index	n20/D 1.521(lit.)
Flash point:	>230 °F
storage temp.	-20°C
form	neat
pka	8.88±0.10(Predicted)
Sensitive	Air Sensitive
BRN	614217
CAS DataBase Reference	15532-75-9(CAS DataBase Reference)
NIST Chemistry Reference	Piperazine, 1-[3-(trifluoromethyl)phenyl]-(15532-75-9)

Safety information for N-(3-Trifluoromethylphenyl)piperazine

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.