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HomeProduct name listN-(3-PYRIDYL)-INDOMETHACIN AMIDE

N-(3-PYRIDYL)-INDOMETHACIN AMIDE

Synonym(s):N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide;N-3PyIA

N-(3-PYRIDYL)-INDOMETHACIN AMIDE Structural

What is N-(3-PYRIDYL)-INDOMETHACIN AMIDE?

The Uses of N-(3-PYRIDYL)-INDOMETHACIN AMIDE

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant COX-2 with IC50 of 0.1 uM

The Uses of N-(3-PYRIDYL)-INDOMETHACIN AMIDE

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant COX-2 with IC50 of 0.1 uM.

What are the applications of Application

N-(3-Pyridyl)indomethacin Amide is a potent and selective reversible Cox-2 inhibitor

Biological Activity

n-(3-pyridyl)-indomethacin amide is a reversible, potent and selective cox-2 inhibitor [1].cyclooxygenase (cox) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1].n-(3-pyridyl)-indomethacin amide (n-3pyia) is a reversible, potent and selective cox-2 inhibitor that inhibits human recombinant cox-2 and ovine cox-1 with ic50 values of 0.052 and >66 μm, respectively. it is over 1300 times less potent as an inhibitor of ovine cox-1. n-(3-pyridyl)-indomethacin amide is the 3-pyridyl amide derivative of indomethacin that shows selective against cox-2 [1].

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

Properties of N-(3-PYRIDYL)-INDOMETHACIN AMIDE

storage temp.  −20°C
solubility  ≤3mg/ml in ethanol;3mg/ml in DMSO;3mg/ml in dimethyl formamide
form  crystalline solid

Safety information for N-(3-PYRIDYL)-INDOMETHACIN AMIDE

Computed Descriptors for N-(3-PYRIDYL)-INDOMETHACIN AMIDE

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