N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
- CAS NO.：302964-08-5
- Empirical Formula: C16H13Cl2N5OS
- Molecular Weight: 394.28
- MDL number: MFCD11045075
- EINECS: 695-686-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
![N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Structural](https://img.chemicalbook.in/CAS/GIF/302964-08-5.gif)
What is N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide?
Description
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a pharmaceutical intermediate compound used as a synthetic intermediate for dasatinib. Dasatinib is a targeted anticancer drug used to treat chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). It is also a receptor and non-receptor Tyk (tyrosine kinase) inhibitor, which plays an important role in certain cancers and fibrotic diseases.
Chemical properties
Pale Yellow Solid
The Uses of N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
Dasatinib intermediate. A protein tyrosine kinase inhibitor.
What are the applications of Application
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a protein tyrosine kinase inhibitor and Dasatinib intermediate
Properties of N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
| Melting point: | 333-335°C |
| Boiling point: | 566.95° C (Predicted) |
| Density | 1.516±0.06 g/cm3(Predicted) |
| refractive index | n20D 1.72 (Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly) |
| form | Solid |
| pka | 10.92±0.70(Predicted) |
| color | Pale Yellow |
| Water Solubility | Slightly soluble in water |
| InChI | InChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22) |
| CAS DataBase Reference | 302964-08-5(CAS DataBase Reference) |
Safety information for N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
| InChIKey | LMXUWARKUIELGT-UHFFFAOYSA-N |
| SMILES | S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(Cl)N=C(C)N=1 |
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