N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
- CAS NO.：171887-03-9
- Empirical Formula: C5H4Cl2N4O
- Molecular Weight: 207.02
- MDL number: MFCD04112936
- EINECS: 425-650-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-16 16:23:18
What is N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide?
Chemical properties
White crystalline powder
The Uses of N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
The Uses of N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
Abacavir intermediate. A purine derivative
The Uses of N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
Prasugrel intermediate
Properties of N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
| Melting point: | >251°C (dec.) |
| Boiling point: | 554.8±60.0 °C(Predicted) |
| Density | 1.742±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | 10.90±0.70(Predicted) |
| color | Off-White to Pale Beige |
| CAS DataBase Reference | 171887-03-9(CAS DataBase Reference) |
Safety information for N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
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