N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

CAS NO.：211311-95-4
Empirical Formula: C19H22N2O2S
Molecular Weight: 342.46
MDL number: MFCD07364003
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-25 23:13:37

What is N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide?

Description

LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1_i, -2_i, -2_o, -3_i, and -4_i subunit-containing AMPA receptors with EC₅₀ values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC₅₀s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.

The Uses of N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

LY 404187 is a novel positive allosteric modulator of AMPA receptors.

storage

Store at +4°C

Properties of N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

Boiling point:	519.0±60.0 °C(Predicted)
Density	1.19±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
form	A solid
pka	11.24±0.40(Predicted)
color	White to off-white