N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
Synonym(s):;SRT1720 - CAS 925434-55-5 - Calbiochem
- CAS NO.：925434-55-5
- Empirical Formula: C25H23N7OS
- Molecular Weight: 469.56
- MDL number: MFCD14584468
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
![N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Structural](https://img.chemicalbook.in/CAS/GIF/925434-55-5.gif)
What is N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide?
General Description
A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10 μM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9 μM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100 mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Also available as a 25 mM solution in DMSO (Cat. No. 530748).
storage
Store at -20°C
Properties of N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
| Melting point: | 221℃ |
| Density | 1.46 |
| storage temp. | -20C |
| solubility | DMSO:5.0(Max Conc. mg/mL);10.65(Max Conc. mM) |
| form | Yellow solid |
| pka | 11.19±0.70(Predicted) |
| color | Light yellow to yellow |
Safety information for N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
Computed Descriptors for N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
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