N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE
- CAS NO.:149649-22-9
- Empirical Formula: C22H27N3O2
- Molecular Weight: 365.47
- MDL number: MFCD00920172
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE?
The Uses of N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE
Nafadotride is a highly potent and competitive dopamine D3 receptor (D3R) antagonist.
Definition
ChEBI: A naphthalenecarboxamide resulting from the formal condensation of the carboxylic acid group of 4-cyano-1-methoxynaphthalene-2-carboxylic acid with the primary amino group of 1-(1-butylpyrrolidin-2-yl]methanamine. It is a highly potent, competitive, prefer ntial dopamine D3 receptor antagonist, centrally active upon systemic administration.
Biological Activity
Highly potent, competitive, preferential dopamine D 3 receptor antagonist. K i values are 0.52, 5, and 269 nM for human cloned D 3 , D 2 and D 4 receptors respectively. Centrally active upon systemic administration.
Properties of N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE
Boiling point: | 556.6±40.0 °C(Predicted) |
Density | 1.17±0.1 g/cm3(Predicted) |
storage temp. | Desiccate at RT |
pka | 12.84±0.46(Predicted) |
Safety information for N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE
Computed Descriptors for N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE
Related products of tetrahydrofuran
4-METHOXY-1-NAPHTHONITRILE
(-)-N[(N-BUTYL-2-PYRROLIDINYL)METHYL]-1-METHOXY-4-CYANONAPHTHALENE-2-CARBOXAMIDE TARTRATE
1-Cyanonaphthalene
N-[(1-BUTYL-2-PYRROLIDINYL)METHYL]-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE
3-Formyl-4-hydroxybenzonitrile
3-CYANO-BENZAMIDE
3-(methylaminomethyl)benzonitrile
3-Cyanobenzaldehyde
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