MYXOTHIAZOL

Synonym(s):Myxothiazol A

CAS NO.：76706-55-3
Empirical Formula: C25H33N3O3S2
Molecular Weight: 487.68
MDL number: MFCD00043397
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:54:58

What is MYXOTHIAZOL?

The Uses of MYXOTHIAZOL

Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.

Definition

ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S

Biochem/physiol Actions

Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.

Properties of MYXOTHIAZOL

Boiling point:	679.6±65.0 °C(Predicted)
Density	1.158±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow
form	Solid
pka	14.07±0.50(Predicted)
color	White to off-white

Safety information for MYXOTHIAZOL

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H300:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. P501:Dispose of contents/container to..…