MYOSMINE
Synonym(s):3-(1-Pyrrolin-2-yl)pyridine;3-(3,4-Dihydro-2H-pyrrol-5-yl)pyridine fumarate salt;Myosmine fumarate fumarate salt
- CAS NO.:532-12-7
- Empirical Formula: C9H10N2
- Molecular Weight: 146.19
- MDL number: MFCD00052019
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-26 14:50:00
What is MYOSMINE?
Description
The alkaloids found in tobacco smoke may be separated into those which are volatile in steam and those which are non-volatile. Myosmine occurs in the former group and, although only present in small quantities, is the most fully investigated of these bases. The alkaloid is normally obtained as an oily liquid which may be crystallized. It is optically inactive and readily soluble in light petroleum or Et20. It forms a hydrochloride as a microcrystalline powder which, on sublimation yields colourless rods, m.p. ISS-8°C. The dihydrochloride, also a microcrystalline powder, yields colourless needles on sublimation, m.p. 1S0- 17 Soc. The base also furnishes a dipicrate, m.p. 182-3°C (dec.) and a dipi_x0002_crolonate, m.p. 204°C (dec.). On dehydrogenation it gives 2-(3'-pyridyl)-pyrrole (picrate, m.p. 200°C) identical with that obtained in a similar manner from nornicotine. According to Woodward and his colleagues, the alkaloid is one of several products formed when nicotine is dehydrogenated over prepared quartz at S70°C. It is readily hydrolyzed in H20 to yield 3-pyridyl-r-aminopropyl ketone, forming a crystalline phenylhydrazone, m.p. 20l-2°C.
Chemical properties
Light Yellow Powder
The Uses of MYOSMINE
Myosmine is an alkaloid found in tobacco. Myosmine has been suspected to be a tobacco-independent carcinogenic source.
The Uses of MYOSMINE
mitogen
The Uses of MYOSMINE
Tobacco alkaloid
Reactant for:
Nitrosation reactions
Peroxidation reaction with hydrogen peroxide
What are the applications of Application
Myosmine is a specific tobacco alkaloid
Definition
ChEBI: Myosmine is a member of the class of pyridines that is pyridine substituted by a 3,4-dihydro-2H-pyrrol-5-yl group at position 3. It is an alkaloid found in tobacco plants and exhibits genotoxic effects. It has a role as a plant metabolite, an EC 1.14.14.14 (aromatase) inhibitor and a mutagen. It is a pyrroline and a pyridine alkaloid.
Synthesis Reference(s)
Canadian Journal of Chemistry, 35, p. 651, 1957 DOI: 10.1139/v57-094
The Journal of Organic Chemistry, 37, p. 1635, 1972
Tetrahedron Letters, 8, p. 5185, 1967
References
Spath, Wenusch, Zajic., Ber., 69, 393 (1936)
Woodward, Eisner, Haines., ibid, 69, 7S7 (1936)
Spath, Wibaut, Kesztler., ibid, 71, 100 (1938)
Properties of MYOSMINE
Melting point: | 42-44°C |
Boiling point: | 82-83°C 0,5mm |
Density | 1.12±0.1 g/cm3(Predicted) |
Flash point: | 82-83°C/0.5mm |
storage temp. | 2-8°C |
solubility | Methanol (Slightly), Water (Sparingly) |
form | Solid |
pka | pK1:5.26 (25°C) |
color | Light Beige to Dark Yellow |
BRN | 119254 |
Stability: | Moisture, Temperature Sensitive |
CAS DataBase Reference | 532-12-7(CAS DataBase Reference) |
Safety information for MYOSMINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for MYOSMINE
Abamectin manufacturer
Acharya Chemicals (Acharya Group)
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