MYOSEVERIN
Synonym(s):9-Isopropyl-N²,N⁶- bis-(4-methoxybenzyl)-9H-purine-2,6-diamine;9-Isopropyl-N²,N⁶-bis-(4-methoxybenzyl)-9H-purine-2,6-diamine;Myoseverin - CAS 267402-71-1 - Calbiochem
- CAS NO.:267402-71-1
- Empirical Formula: C24H28N6O2
- Molecular Weight: 432.52
- MDL number: MFCD02683596
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:48
What is MYOSEVERIN?
The Uses of MYOSEVERIN
Myoseverin is a microtubule interfering agent resulting in adverse cellular function. It affects a variety of growth factor, immunomodulatory, extracellular matrix remodelling and stress-response genes. This activity is consistent with the activation of pathways involving tissue regeneration and healing.
What are the applications of Application
Myoseverin is an inducer of multinucleated myotubule fission
Biological Activity
myoseverin is a novel microtubule-binding molecule.microtubules are dynamic filamentous cytoskeletal proteins, which are composed of tubulin and are an critical therapeutic target in tumour cells. drugs binding to microtubules have been the first-line standard of anticancer therapy for decades and until the advent of targeted therapy.
in vitro
myoseverin was found to be able to induce the reversible fission of multinucleated myotubes into mononucleated fragments. in addition, cell proliferation and myotube fission promoted dna synthesis after myoseverin removal and transfer of the cells to the fresh growth medium. moreover, the biochemical analysis and transcriptional profiling showed that myoseverin alone did not reverse the processes of biochemical differentiation. however, myoseverin could affect the expression of various growth factor, extracellular matrix-remodeling, immunomodulatory, as well as stress response genes, which was consistent with the activation of pathways involved in tissue regeneration and wound healing [1]. another study found that myoseverin-treated cardiac myocytes showed disruptions of the striated z-bands with alpha-actinin and desmin. similarly, active stathmin expression did not prevent the assembly of sarcomere. moreover, the extent of mt destabilization caused by myoseverin and nocodazole were comparable [2].
References
[1] rosania gr,chang yt,perez o,sutherlin d,dong h,lockhart dj,schultz pg. myoseverin, a microtubule-binding molecule with novel cellular effects. nat biotechnol.2000 mar;18(3):304-8.
[2] ng dc,gebski bl,grounds md,bogoyevitch ma. myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition. cell motil cytoskeleton.2008 jan;65(1):40-58.
Properties of MYOSEVERIN
Melting point: | 106.0 to 110.0 °C |
Boiling point: | 661.3±65.0 °C(Predicted) |
Density | 1.24±0.1 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | chloroform: 50 mg/mL, soluble |
form | solid |
pka | 4.65±0.30(Predicted) |
color | off-white |
CAS DataBase Reference | 267402-71-1 |
Safety information for MYOSEVERIN
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for MYOSEVERIN
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