MUCONOMYCIN A
Synonym(s):Muconomycin A
- CAS NO.：3148-09-2
- Empirical Formula: C27H34O9
- Molecular Weight: 502.55
- MDL number: MFCD00056759
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:14
What is MUCONOMYCIN A?
The Uses of MUCONOMYCIN A
Verrucarin A from Myrothecium sp has been used:
- as a translation initiation inhibitor in P. falciparum W2 strain
- as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells
- to test its cytotoxicity in renal cell carcinoma cells
Definition
ChEBI: A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.
General Description
Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.
Biochem/physiol Actions
Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells
Properties of MUCONOMYCIN A
| Melting point: | >360° (dec) |
| Boiling point: | 512.66°C (rough estimate) |
| alpha | D23 +206° (c = 1.012 in chloroform) |
| Density | 1.1922 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | −20°C |
| solubility | Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| pka | 12.76±0.70(Predicted) |
| form | A solid |
| color | White to light yellow |
Safety information for MUCONOMYCIN A
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for MUCONOMYCIN A
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