MUCONOMYCIN A

Synonym(s):Muconomycin A

CAS NO.：3148-09-2
Empirical Formula: C27H34O9
Molecular Weight: 502.55
MDL number: MFCD00056759
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:14

What is MUCONOMYCIN A?

The Uses of MUCONOMYCIN A

Verrucarin A from Myrothecium sp has been used:

as a translation initiation inhibitor in P. falciparum W2 strain
as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells
to test its cytotoxicity in renal cell carcinoma cells

Definition

ChEBI: A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.

General Description

Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.

Biochem/physiol Actions

Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells

Properties of MUCONOMYCIN A

Melting point:	>360° (dec)
Boiling point:	512.66°C (rough estimate)
alpha	D23 +206° (c = 1.012 in chloroform)
Density	1.1922 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	−20°C
solubility	Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
pka	12.76±0.70(Predicted)
form	A solid
color	White to light yellow

Safety information for MUCONOMYCIN A

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection.