Mubritinib

Synonym(s):(E)-4-((4-(4-(1H-1,2,3-triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole;1-[4-[4-[[2-[(1E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole;CID 6444692;TAK 165;TAK-165

CAS NO.：366017-09-6
Empirical Formula: C25H23F3N4O2
Molecular Weight: 468.47
MDL number: MFCD09954135
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-30 15:45:59

What is Mubritinib?

The Uses of Mubritinib

Mubritinib is used in selective targeting of CTNNB1-, KRAS-or MYC-driven human cancer cell growth by combinations of existing drugs

The Uses of Mubritinib

Treatment of cancer.

What are the applications of Application

TAK 165 is a selective, potent, and irreversible ErbB2 and EGFR inhibitor

Biological Activity

Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC 50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC 50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo .

storage

Store at +4°C

Properties of Mubritinib

Melting point:	158.0 to 162.0 °C
Boiling point:	620.9±65.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	DMSO : 50 mg/mL (106.73 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka	1.45±0.10(Predicted)
form	powder to crystal
color	White to Gray to Brown

Safety information for Mubritinib

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H320:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.