Mosapride citrate
- CAS NO.:112885-42-4
- Empirical Formula: C27H33ClFN3O10
- Molecular Weight: 614.02
- MDL number: MFCD00874415
- EINECS: 601-211-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is Mosapride citrate?
Description
Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.
The Uses of Mosapride citrate
As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.
The Uses of Mosapride citrate
Mosapride Citrate is a selective SR-4 activator and a SR-3 inhibitor.
What are the applications of Application
Mosapride citrate is a selective SR-4 activator and a SR-3 inhibitor
Biological Activity
5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.
storage
room temperature (desiccate)
Properties of Mosapride citrate
Melting point: | 143-145° |
storage temp. | Inert atmosphere,2-8°C |
solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated) |
form | Solid |
color | White to Off-White |
Stability: | Hygroscopic |
CAS DataBase Reference | 112885-42-4(CAS DataBase Reference) |
Safety information for Mosapride citrate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Mosapride citrate
Abamectin manufacturer
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