Monomethyl adipate
Synonym(s):Adipic acid monomethyl ester;Monomethyl adipate
- CAS NO.:627-91-8
- Empirical Formula: C7H12O4
- Molecular Weight: 160.17
- MDL number: MFCD00004418
- EINECS: 211-019-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is Monomethyl adipate?
Chemical properties
clear colorless liquid
The Uses of Monomethyl adipate
Methyl hydrogen adipate is a useful synthetic intermediate. It can be used to prepare 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors which show potential antitumor activities. It can be also used to synthesize mannose-linked biphenylylacetic acid derivatives as novel inhibitors of selectin-mediated cell adhesion.
What are the applications of Application
mono-Methyl adipate is a useful synthetic intermediate
Definition
ChEBI: Monomethyl adipate is a dicarboxylic acid monoester that is the monomethyl ester of adipic acid. It has a role as a metabolite and a plasticiser.
Synthesis
According to the general procedure described above, a has been synthesized from adipic acid (730mg, 5 mmol) and methanol (10 ml). Yield: 80%.
The synthetic method of Monomethyl adipate mainly contains following three kinds:
The one, under alkaline condition or issue the first portion hydrolysis reaction in the catalysis of bioactive enzyme (pork liver lipase etc.) and obtain Monomethyl adipate (such as document Blaise; Koehler; Bulletin de la Societe Chimique deFrance; Vol. (4) 7; (1910); P.219).
The 2nd, by hexanodioic acid or adipic anhydride and ethanol, as catalyzer, the control reaction conditions carries out esterification and obtains Monomethyl adipate (such as document Chem.Zentralbl. with acid; Vol.97; (1926; P.126));
The 3rd, by the people such as Swann nineteen forty-three with hexanodioic acid, diethylene adipate and ethanol with the condition of acid as catalyst under control reaction conditions obtain monomethyl adipate(document such as Swann; Oehler; Buswell; Org.synth.Coll.Vol.11; (1943); P.227).
Synthetic method of monomethyl adipate
http://www.orgsyn.org/demo.aspx?prep=CV2P0264
Properties of Monomethyl adipate
Melting point: | 7-9 °C (lit.) |
Boiling point: | 162 °C/10 mmHg (lit.) |
Density | 1.081 g/mL at 25 °C (lit.) |
vapor pressure | 1.48Pa at 25℃ |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Sparingly), Methanol (Slightly) |
pka | 4.69±0.10(Predicted) |
form | Liquid |
color | Clear colorless |
Water Solubility | Not miscible or difficult to mix with water. |
BRN | 1766411 |
CAS DataBase Reference | 627-91-8(CAS DataBase Reference) |
NIST Chemistry Reference | Hexanedioic acid, monomethyl ester(627-91-8) |
EPA Substance Registry System | Monomethyl adipate (627-91-8) |
Safety information for Monomethyl adipate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Monomethyl adipate
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