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HomeProduct name listMonomethyl adipate

Monomethyl adipate

Synonym(s):Adipic acid monomethyl ester;Monomethyl adipate

  • CAS NO.:627-91-8
  • Empirical Formula: C7H12O4
  • Molecular Weight: 160.17
  • MDL number: MFCD00004418
  • EINECS: 211-019-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
Monomethyl adipate Structural

What is Monomethyl adipate?

Chemical properties

clear colorless liquid

The Uses of Monomethyl adipate

Methyl hydrogen adipate is a useful synthetic intermediate. It can be used to prepare 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors which show potential antitumor activities. It can be also used to synthesize mannose-linked biphenylylacetic acid derivatives as novel inhibitors of selectin-mediated cell adhesion.

What are the applications of Application

mono-Methyl adipate is a useful synthetic intermediate

Definition

ChEBI: Monomethyl adipate is a dicarboxylic acid monoester that is the monomethyl ester of adipic acid. It has a role as a metabolite and a plasticiser.

Synthesis

According to the general procedure described above, a has been synthesized from adipic acid (730mg, 5 mmol) and methanol (10 ml). Yield: 80%.
The synthetic method of Monomethyl adipate mainly contains following three kinds:
The one, under alkaline condition or issue the first portion hydrolysis reaction in the catalysis of bioactive enzyme (pork liver lipase etc.) and obtain Monomethyl adipate (such as document Blaise; Koehler; Bulletin de la Societe Chimique deFrance; Vol. (4) 7; (1910); P.219).
The 2nd, by hexanodioic acid or adipic anhydride and ethanol, as catalyzer, the control reaction conditions carries out esterification and obtains Monomethyl adipate (such as document Chem.Zentralbl. with acid; Vol.97; (1926; P.126));
The 3rd, by the people such as Swann nineteen forty-three with hexanodioic acid, diethylene adipate and ethanol with the condition of acid as catalyst under control reaction conditions obtain monomethyl adipate(document such as Swann; Oehler; Buswell; Org.synth.Coll.Vol.11; (1943); P.227).
Synthetic method of monomethyl adipate
http://www.orgsyn.org/demo.aspx?prep=CV2P0264

Properties of Monomethyl adipate

Melting point: 7-9 °C (lit.)
Boiling point: 162 °C/10 mmHg (lit.)
Density  1.081 g/mL at 25 °C (lit.)
vapor pressure  1.48Pa at 25℃
refractive index  n20/D 1.441(lit.)
Flash point: >230 °F
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Sparingly), Methanol (Slightly)
pka 4.69±0.10(Predicted)
form  Liquid
color  Clear colorless
Water Solubility  Not miscible or difficult to mix with water.
BRN  1766411
CAS DataBase Reference 627-91-8(CAS DataBase Reference)
NIST Chemistry Reference Hexanedioic acid, monomethyl ester(627-91-8)
EPA Substance Registry System Monomethyl adipate (627-91-8)

Safety information for Monomethyl adipate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Monomethyl adipate

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