MOLLUGIN
Synonym(s):6-Hydroxy-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5-carboxylic acid methyl ester;Rubimaillin
- CAS NO.:55481-88-4
- Empirical Formula: C17H16O4
- Molecular Weight: 284.31
- MDL number: MFCD02752331
- EINECS: 683-209-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is MOLLUGIN?
The Uses of MOLLUGIN
Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models.
Definition
ChEBI: Rubimaillin is a benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme. It has a role as a plant metabolite, an acyl-CoA:cholesterol acyltransferase 2 inhibitor, a NF-kappaB inhibitor, an antineoplastic agent, an apoptosis inducer, a neuroprotective agent and an anti-inflammatory agent. It is a benzochromene, a methyl ester and a member of phenols.
Properties of MOLLUGIN
Melting point: | 132~134℃ |
Boiling point: | 453.2±45.0 °C(Predicted) |
Density | 1.239±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
form | Solid |
pka | 8.40±0.40(Predicted) |
color | Yellow to Green |
Safety information for MOLLUGIN
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for MOLLUGIN
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