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HomeProduct name listMOLLUGIN

MOLLUGIN

Synonym(s):6-Hydroxy-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5-carboxylic acid methyl ester;Rubimaillin

  • CAS NO.:55481-88-4
  • Empirical Formula: C17H16O4
  • Molecular Weight: 284.31
  • MDL number: MFCD02752331
  • EINECS: 683-209-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
MOLLUGIN Structural

What is MOLLUGIN?

The Uses of MOLLUGIN

Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models.

Definition

ChEBI: Rubimaillin is a benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme. It has a role as a plant metabolite, an acyl-CoA:cholesterol acyltransferase 2 inhibitor, a NF-kappaB inhibitor, an antineoplastic agent, an apoptosis inducer, a neuroprotective agent and an anti-inflammatory agent. It is a benzochromene, a methyl ester and a member of phenols.

Properties of MOLLUGIN

Melting point: 132~134℃
Boiling point: 453.2±45.0 °C(Predicted)
Density  1.239±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Chloroform (Slightly), Ethyl Acetate (Slightly)
form  Solid
pka 8.40±0.40(Predicted)
color  Yellow to Green

Safety information for MOLLUGIN

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for MOLLUGIN

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