ASARININ

CAS NO.：133-04-0
Empirical Formula: C20H18O6
Molecular Weight: 354.35
MDL number: MFCD00198067
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-03 11:32:31

What is ASARININ?

Description

Asarinin is a lignan that has been found in A. sieboldii. It is an epimer of sesamin and a noncompetitive inhibitor of Δ⁵-desaturase (K_i = 0.28 mM). It is selective for Δ⁵-desaturase over Δ⁶- and Δ⁹-desaturase. Asarinin is cytotoxic to A2780 and SKOV3 ovarian cancer cells (IC₅₀s = 38.45 and 60.87 μM, respectively) but not immortalized ovarian surface epithelial cells (IC₅₀ = >200 μM). It induces apoptosis and activates caspase-3, -8, and -9 in A2780 and SKOV3 cells.

The Uses of ASARININ

l-Asarinin in combination with pellitorine is a potential larvicides for the control of insecticide-resistant mosquito populations. Possesses antimicrobial activity.

Properties of ASARININ

Melting point:	121°
Boiling point:	504.4±50.0 °C(Predicted)
alpha	D20 -118.6°; D23 -122° (chloroform)
Density	1.385±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), DMSO (Slightly, Sonicated)
form	Solid
color	White to Off-White

Safety information for ASARININ

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.