Molidustat(BAY 85-3934)
- CAS NO.:1154028-82-6
- Empirical Formula: C13H14N8O2
- Molecular Weight: 314.3
- MDL number: MFCD28411428
- EINECS: 815-038-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:16
What is Molidustat(BAY 85-3934)?
Description
Hypoxia-inducible factor (HIF) is the major transcription factor involved in erythropoietin gene expression. Because oxygen-
in vitro
the ic50 values were found to be dependent on the 2-oxoglutarate concentration in the reaction buffer. by lowering the 2-oxoglutarate concentration from 20 μm to 0.3 μm, the potency of the test compound increased up to 10-fold. variation of the concentrations of fe2+ and ascorbate in the reaction buffer by factors of 30 and 200, respectively, did not alter the potency of the inhibitor by more than 2-fold [1].
in vivo
in repeat dosing of bay 85-3934, hemoglobin levels were increased compared with animals in vehicle group, while endogenous epo remained within the normal physiological range. bay 85-3934 therapy was also effective in the treatment of renal anemia in rats with impaired kidney function and, unlike treatment with rhepo, resulted in normalization of hypertensive blood pressure in a rat model of ckd [1].
References
[1] flamme i, oehme f, ellinghaus p, jeske m, keldenich j, thuss u. mimicking hypoxia to treat anemia: hif-stabilizer bay 85-3934 (molidustat) stimulates erythropoietin production without hypertensive effects. plos one. 2014 nov 13;9(11):e111838.
Properties of Molidustat(BAY 85-3934)
Boiling point: | 589.2±60.0 °C(Predicted) |
Density | 1.67±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | insoluble in EtOH; insoluble in H2O; ≥5.68 mg/mL in DMF |
form | solid |
pka | 5.38±0.37(Predicted) |
color | White to off-white |
Safety information for Molidustat(BAY 85-3934)
Computed Descriptors for Molidustat(BAY 85-3934)
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