MK-4827 (R-enantioMer)
- CAS NO.：1038915-58-0
- Empirical Formula: C19H20N4O
- Molecular Weight: 320.39
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 13:17:44
What is MK-4827 (R-enantioMer)?
The Uses of MK-4827 (R-enantioMer)
ent-Niraparib is an isomer of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Definition
ChEBI: 2-{4-[(3R)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has R-configuration. It is a potent PARP1 inhibitor with IC50 of 2.4 nM. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an antineoplastic agent.
Properties of MK-4827 (R-enantioMer)
| Boiling point: | 463.6±45.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 32 mg/mL (99.88 mM) |
| form | Solid |
| pka | 15.36±0.30(Predicted) |
| color | Light yellow to yellow |
Safety information for MK-4827 (R-enantioMer)
Computed Descriptors for MK-4827 (R-enantioMer)
New Products
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