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HomeProduct name listmitopodozide

mitopodozide

  • CAS NO.:1508-45-8
  • Empirical Formula: C24H30N2O8
  • Molecular Weight: 474.507
  • MDL number: MFCD01699021
  • EINECS: 2161381
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
mitopodozide Structural

What is mitopodozide?

Originator

Proresid,Sandoz,W. Germany,1966

Definition

ChEBI: Mitopodozide is a lignan.

Manufacturing Process

500 g of podophyllinic acid hydrazide are heated together with 150 cc of acetaldehyde with 2,200 cc of methanol to 40°C. The solution obtained is filtered and then cooled. The product which crystallizes out is filtered off with suction and washed with methanol. Together with a second fraction obtained after concentration of the mother liquors there are produced 450 g of podophyllinic acid ethylidene hydrazide, having a melting point of 222°C to 224°C and a specific rotation of [α]D = -285° (c. = 0.5 in ethanol).
The product is hydrogenated in 4,000 cc of ethanol at room temperature and under normal atmospheric pressure with a catalyst prepared in the usual manner from 400 g of Raney nickel alloy. The calculated amount of hydrogen is taken up in approximately 75 hours. After filtration and evaporation to a small volume, the residue is distributed between 1,000 cc of chloroform and water each. The chloroform solution is then dried over sodium sulfate and evaporated toa small volume. Precipitation of the hydrogenation product with petroleum ether yields an amorphous white powder which is filtered by suction, washed with petroleum ether and dried at 50°C in a high vacuum. 1- ethyl-2-podophyllinic acid hydrazide is obtained in a practically quantitative yield.

Therapeutic Function

Antineoplastic

Properties of mitopodozide

Melting point: 100-120 °C
Boiling point: 619.6±55.0 °C(Predicted)
alpha  D -154° (c = 0.5 in chloroform)
Density  1.301±0.06 g/cm3(Predicted)
pka 12.79±0.70(Predicted)

Safety information for mitopodozide

Computed Descriptors for mitopodozide

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