MI-3 (Menin-MLL Inhibitor)
- CAS NO.：1271738-59-0
- Empirical Formula: C18H25N5S2
- Molecular Weight: 375.55
- MDL number: MFCD28348362
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is MI-3 (Menin-MLL Inhibitor)?
Description
MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 648 nM). MI-3 binds to menin (Kd = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.
The Uses of MI-3 (Menin-MLL Inhibitor)
MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia.
Properties of MI-3 (Menin-MLL Inhibitor)
| Boiling point: | 527.9±60.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic) |
| form | Powder |
| pka | 9.59±0.40(Predicted) |
| color | Light yellow to yellow |
Safety information for MI-3 (Menin-MLL Inhibitor)
Computed Descriptors for MI-3 (Menin-MLL Inhibitor)
New Products
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