MG-115
Synonym(s):Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII;MG115;MG-115 - CAS 133407-86-0 - Calbiochem;Z-LLnV
- CAS NO.:133407-86-0
- Empirical Formula: C25H39N3O5
- Molecular Weight: 461.59
- MDL number: MFCD00274411
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:50:00
What is MG-115?
Description
(S)-
The Uses of MG-115
MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.
The Uses of MG-115
(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical]
What are the applications of Application
MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome
Definition
ChEBI: N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamic acid (phenylmethyl) ester is a peptide.
General Description
Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).
Biochem/physiol Actions
Product does not compete with ATP.
References
1. involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. imamura, t., haruta, t., takata, y., usui, i., iwata, m., ishihara, h., ishiki, m., ishibashi, o., ueno, e., sasaoka, t., kobayashi, m. j. biol. chem. (1998)
Properties of MG-115
Boiling point: | 678.8±55.0 °C(Predicted) |
Density | 1.082±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO: soluble |
form | powder |
pka | 11.14±0.46(Predicted) |
color | white |
Safety information for MG-115
Computed Descriptors for MG-115
Related products of tetrahydrofuran
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