Methylophiopogonanone A
- CAS NO.：74805-92-8
- Empirical Formula: C19H18O6
- Molecular Weight: 342.34
- MDL number: MFCD11111461
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-01 17:37:15
What is Methylophiopogonanone A?
Description
Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities. It increases the uptake of rosuvastatin (Item Nos. 12029 | 18813) and atorvastatin in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC50s = 11.33 and 6 μM, respectively). Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals in cell-free assays. In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia. It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery.
Definition
ChEBI: Methylophiopogonanone A is a homoflavonoid.
Properties of Methylophiopogonanone A
| Boiling point: | 580.1±50.0 °C(Predicted) |
| Density | 1.410 |
| solubility | Soluble in chloroform and methanol; |
| form | powder |
| pka | 8.24±0.40(Predicted) |
| color | Light yellow |
| Water Solubility | insoluble in water |
Safety information for Methylophiopogonanone A
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methylophiopogonanone A
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