Methylophiopogonanone A

CAS NO.：74805-92-8
Empirical Formula: C19H18O6
Molecular Weight: 342.34
MDL number: MFCD11111461
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 15:53:33

What is Methylophiopogonanone A?

Description

Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities. It increases the uptake of rosuvastatin (Item Nos. 12029 | 18813) and atorvastatin in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC₅₀s = 11.33 and 6 μM, respectively). Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals in cell-free assays. In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia. It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery.

Definition

ChEBI: Methylophiopogonanone A is a homoflavonoid.

Properties of Methylophiopogonanone A

Boiling point:	580.1±50.0 °C(Predicted)
Density	1.410
solubility	Soluble in chloroform and methanol;
form	powder
pka	8.24±0.40(Predicted)
color	Light yellow
Water Solubility	insoluble in water

Safety information for Methylophiopogonanone A

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.