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HomeProduct name listMethylene boldenone

Methylene boldenone

Methylene boldenone Structural

What is Methylene boldenone?

Description

17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.

Chemical properties

Off-White Solid

The Uses of Methylene boldenone

A metabolite of Exemestane; exerts biological effects as an androgen.

The Uses of Methylene boldenone

17β-Hydroxy Exemestane Sulfamate is a metabolite of Exemestane (E957000).

Properties of Methylene boldenone

Melting point: 134-136°C
Density  1.14
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
color  Off-White
CAS DataBase Reference 122370-91-6

Safety information for Methylene boldenone

Computed Descriptors for Methylene boldenone

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