Methyl trifluoroacetate

CAS NO.：431-47-0
Empirical Formula: C3H3F3O2
Molecular Weight: 128.05
MDL number: MFCD00000417
EINECS: 207-074-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 13:37:16

What is Methyl trifluoroacetate?

Chemical properties

clear colorless liquid

The Uses of Methyl trifluoroacetate

Methyl trifluoroacetate has been used as reagent for trifluoroacetylation of amines and amino acids.

Synthesis Reference(s)

Journal of the American Chemical Society, 113, p. 700, 1991 DOI: 10.1021/ja00002a063

General Description

Methyl trifluoroacetate along with cesium fluoride or cesium chloride and CuI constitutes a valuable trifluoromethylating reagent for substituting aromatic (or heteroaromatic) iodides and bromides. Adsorption of methyl trifluoroacetate on amorphous silica has been investigated. Fragmentation mechanism of generation of metastable ions from methyl trifluoroacetate has been investigated by mass analyzed ion kinetic energy spectra and ab initio molecular orbital calculations.

Flammability and Explosibility

Flammable

Properties of Methyl trifluoroacetate

Melting point:	-78 °C
Boiling point:	43-43.5 °C (lit.)
Density	1.273 g/mL at 25 °C (lit.)
vapor pressure	5.77 psi ( 20 °C)
refractive index	n20/D 1.291(lit.)
Flash point:	19 °F
storage temp.	Inert atmosphere,2-8°C
solubility	8g/l
form	Liquid
color	Clear colorless
Specific Gravity	1.273
PH	7 (8g/l, H2O, 20℃)
explosive limit	6.1-24.8%(V)
Water Solubility	8 g/L
Sensitive	Moisture Sensitive
BRN	1756070
Dielectric constant	11.460000000000001
Stability:	Volatile
CAS DataBase Reference	431-47-0(CAS DataBase Reference)
NIST Chemistry Reference	CF3C(O)OCH3(431-47-0)
EPA Substance Registry System	Acetic acid, trifluoro-, methyl ester (431-47-0)

Safety information for Methyl trifluoroacetate

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05
GHS Hazard Statements	H225:Flammable liquids H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.