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HomeProduct name listMethyl trichloroacetate

Methyl trichloroacetate

  • CAS NO.:598-99-2
  • Empirical Formula: C3H3Cl3O2
  • Molecular Weight: 177.41
  • MDL number: MFCD00000794
  • EINECS: 209-960-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-11-28 16:31:44
Methyl trichloroacetate Structural

What is Methyl trichloroacetate?

Chemical properties

Colorless clear liquid

The Uses of Methyl trichloroacetate

Methyl trichloroacetate was used for negative staining of protein that allowed unmodified proteins to be recovered for biological studies or transblot for amino acid sequence.

What are the applications of Application

Methyl trichloroacetate is a precursor of dichlorocarbene.

Reactions

methyl trichloroacetate reacts with sodium methoxide then the formed product is carbine.

Synthesis Reference(s)

Tetrahedron Letters, 20, p. 3643, 1979 DOI: 10.1016/S0040-4039(01)95485-1

General Description

Methyl trichloroacetate appears as a colorless liquid. Insoluble in water and denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. A mixture of the ester and trimethylamine reacted violently. Polymerization of a reactive dehydrochlorination of the ester was viewed as the most likely product, along with generous amounts of heat.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Properties of Methyl trichloroacetate

Melting point: -18°C
Boiling point: 152-153 °C (lit.)
Density  1.488 g/mL at 25 °C (lit.)
refractive index  n20/D 1.455(lit.)
Flash point: 163 °F
storage temp.  room temp
solubility  1050mg/l
form  clear liquid
color  Colorless to Almost colorless
Water Solubility  Insoluble in water
BRN  1756075
Dielectric constant 8.7899999999999991
CAS DataBase Reference 598-99-2(CAS DataBase Reference)
NIST Chemistry Reference Acetic acid, trichloro-, methyl ester(598-99-2)
EPA Substance Registry System Acetic acid, 2,2,2-trichloro-, methyl ester (598-99-2)

Safety information for Methyl trichloroacetate

Signal word Warning
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H227:Flammable liquids
H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H331:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for Methyl trichloroacetate

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