Methyl nitroacetate
- CAS NO.：2483-57-0
- Empirical Formula: C3H5NO4
- Molecular Weight: 119.08
- MDL number: MFCD00075480
- EINECS: 219-622-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-15 16:23:59
What is Methyl nitroacetate?
Chemical properties
clear yellow liquid
The Uses of Methyl nitroacetate
Methyl nitroacetate is used in the synthesis of aromatic and heteroaromatic linear (E)-alfa-nitro-arylpentenoates. It is also used to prepare phenyliodonium ylide. Further, it is utilized in the highly enantioselective and diastereoselective copper(I)-catalyzed cyclopropanation of alkenes. In addition to this, it is employed in the production of methyl (Z)-2-nitro-3-(4-nitrophenyl)-2-propenoate through reaction with 4-nitrobenzylideneaniline.
Synthesis Reference(s)
The Journal of Organic Chemistry, 25, p. 266, 1960 DOI: 10.1021/jo01072a606
Properties of Methyl nitroacetate
| Boiling point: | 195-198 °C (lit.) |
| Density | 1.294 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 221 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Miscible with ethanol, ether and most organic solvents. |
| form | clear liquid |
| pka | 5.73±0.29(Predicted) |
| color | Colorless to Light yellow |
| Sensitive | Light Sensitive |
| BRN | 1758670 |
| CAS DataBase Reference | 2483-57-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, nitro-, methyl ester(2483-57-0) |
Safety information for Methyl nitroacetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methyl nitroacetate
| InChIKey | ALBSWLMUHHZLLR-UHFFFAOYSA-N |
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