Methyl isonipecotate

Synonym(s):Methyl 4-piperidinecarboxylate

CAS NO.：2971-79-1
Empirical Formula: C7H13NO2
Molecular Weight: 143.18
MDL number: MFCD00190578
EINECS: 629-683-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-12-18 16:59:08

What is Methyl isonipecotate?

Chemical properties

Colorless liquid

The Uses of Methyl isonipecotate

Methyl piperidine-4-carboxylate is a reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation. It is used as a reactant for synthesis of antitubercular agents, aminopyrazine inhibitors, orally available naphthyridine protein kinase D inhibitors and a scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide.

The Uses of Methyl isonipecotate

Methyl isonipecotate may be used for the synthesis of a series of potent non-urea soluble epoxide hydrolase (sEH) inhibitors via high throughput screens.

The Uses of Methyl isonipecotate

4-Piperidinecarboxylic acid methyl ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds.

What are the applications of Application

Methyl isonipecotate is a reactant for C-2 arylation of piperidines

General Description

Methyl isonipecotate can be obtained by the reduction of methyl isonicotinate in methanol with ruthenium at 100-150°C.

Properties of Methyl isonipecotate

Boiling point:	85-90 °C (lit.)
Density	1.06 g/mL at 25 °C (lit.)
refractive index	1.465
Flash point:	192°F
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	Chloroform
form	Liquid
pka	9.78±0.10(Predicted)
color	Colorless to yellow
Water Solubility	Slightly soluble in water.
CAS DataBase Reference	2971-79-1(CAS DataBase Reference)

Safety information for Methyl isonipecotate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.