4-(Hydroxyamino)-4-oxobutanoic acid

CAS NO.：4743-99-1
Empirical Formula: C4H7NO4
Molecular Weight: 133.1
EINECS: 225-255-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-13 17:19:14

What is 4-(Hydroxyamino)-4-oxobutanoic acid?

Preparation

To a refluxing solution of 5.0 gm (0.05 mole) of succinic anhydride in 100 ml of benzene is added a solution of 6.3 gm (0.05 mole) of O-ben- zylhydroxylamine in 20 ml of benzene. As soon as the addition has been completed, the reaction mixture is cooled, and the precipitated product is separated. Upon recrystallization from a benzene-methyl ethyl ketone mixture, 7.6 gm (68.2%) of N-benzyloxysuccinamic acid, m.p. 95-96°C isolated.
A suspension of 4.3 gm (0.0193 mole) of this intermediate and a stron- tium carbonate catalyst containing 5% palladium in methyl ethyl ketone is hydrogenated. Upon working up the reaction mixture, 1.45 gm (56.7%) of succinomonohydroxamic acid, m.p. 95-96°C is isolated.
Preparation of N-Hydroxysuccinamic Acid

Properties of 4-(Hydroxyamino)-4-oxobutanoic acid

Melting point:	82-86 °C(Solv: acetonitrile (75-05-8))
Density	1.436±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
pka	5.28±0.10(Predicted)

Safety information for 4-(Hydroxyamino)-4-oxobutanoic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.