methyl 6-(bromomethyl)nicotinate
- CAS NO.：131803-48-0
- Empirical Formula: C8H8BrNO2
- Molecular Weight: 230.06
- MDL number: MFCD10566280
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-08 14:16:06
What is methyl 6-(bromomethyl)nicotinate?
The Uses of methyl 6-(bromomethyl)nicotinate
methyl 6-(bromomethyl)nicotinate is an organic reagent mainly used in chemical and scientific laboratory research.
Synthesis
methyl 6-(bromomethyl)nicotinate is synthesised using methyl 6-methylnicotinate as a raw material by chemical reaction. The specific synthesis steps are as follows:
0.471 g (1.0 equivalent) of N-bromosuccinimide and 64 mg (0.1 equivalent) of benzoyl peroxide are added to a solution of 0.4 g of the product obtained in the preceding Stage 1 in 15 ml of carbon tetrachloride. The solution is brought to reflux for 6 hours, then filtered and evaporated under reduced pressure. The residue is purified by chromatography on silica gel (dichloromethane/ethyl acetate: 95/5) to produce 0.262 g of the expected product. [ Yield: 43percent MS: MH+ 231].
Properties of methyl 6-(bromomethyl)nicotinate
| Boiling point: | 284.9±30.0℃ (760 Torr) |
| Density | 1.533±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point: | 126.1±24.6℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 1.40±0.22(Predicted) |
| form | solid |
| color | OFF WHITE |
Safety information for methyl 6-(bromomethyl)nicotinate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for methyl 6-(bromomethyl)nicotinate
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