Methyl 4-hydroxycinnamate

CAS NO.：3943-97-3
Empirical Formula: C10H10O3
Molecular Weight: 178.18
MDL number: MFCD24849120
EINECS: 223-531-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

What is Methyl 4-hydroxycinnamate?

Description

Methyl 4-hydroxycinnamate is an atifungal agent and a cinnamic acid derivative used in structure-antifungal activity relationship studies against Aspergillus flavus, Aspergillus terreus, and Aspergillus niger.

Occurrence

Methyl 4-hydroxycinnamate isolated from the herbs of Piper longum, Alpinia blepharocalyx, and Grevillea robusta.

The Uses of Methyl 4-hydroxycinnamate

3-(4-Hydroxyphenyl)-2-propenoic Acid Methyl Ester is used in the synthesis of AB3 and constitutional isomeric AB2 phenylpropyl ether-based supramolecular dendrimers. Also used in the synthesis of potent antagonists of leukotrines.

Definition

ChEBI: 4-coumaric acid methyl ester is a cinnamate ester that is the methyl ester of 4-coumaric acid. It has a role as a melanin synthesis inhibitor, a fungal metabolite, an anti-inflammatory agent, an antifungal agent and a plant metabolite. It is a cinnamate ester, a member of phenols and a methyl ester. It derives from a 4-coumaric acid.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 28, p. 3662, 1980 DOI: 10.1248/cpb.28.3662

Properties of Methyl 4-hydroxycinnamate

Melting point:	144-145°
Boiling point:	306.6±17.0 °C(Predicted)
Density	1?+-.0.06 g/cm3(Predicted)
vapor pressure	0.056Pa at 25℃
storage temp.	Inert atmosphere,Room Temperature
pka	8.82±0.13(Predicted)
color	White
Water Solubility	5.332g/L at 25℃
CAS DataBase Reference	3943-97-3(CAS DataBase Reference)
NIST Chemistry Reference	2-Propenoic acid, 3-(4-hydroxyphenyl)-, methyl ester(3943-97-3)

Safety information for Methyl 4-hydroxycinnamate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.