Methyl 2-acetamidoacrylate

CAS NO.：35356-70-8
Empirical Formula: C6H9NO3
Molecular Weight: 143.14
MDL number: MFCD00013394
SAFETY DATA SHEET (SDS)
Update Date: 2023-07-12 17:16:24

What is Methyl 2-acetamidoacrylate?

The Uses of Methyl 2-acetamidoacrylate

Methyl 2-acetamidoacrylate exhibits anti-inflammatory property and decreases induced acute kidney injury in mice.

What are the applications of Application

Methyl 2-acetamidoacrylate is an ethyl pyruvate analog that exhibits anti-inflammatory properties

General Description

Conjugated addition of secondary amines, imidazole and pyrazole to methyl 2 methyl 2-acetamidoacrylate in the presence of a catalyst results in the formation of β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives. Methyl-2-acetamidoacrylate (M2AA) is an anti-inflammatory agent. The catalytic reaction of methyl 2-acetamidoacrylate with Grignard′s reagents affords α-amino esters. M2AA can form thermosensitive copolymers with methyl acrylate.

Properties of Methyl 2-acetamidoacrylate

Melting point:	50-52 °C (lit.)
Boiling point:	104 °C/8 mmHg (lit.)
Density	1.3075 (rough estimate)
refractive index	1.4340 (estimate)
Flash point:	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	13.12±0.46(Predicted)
color	Off-White
BRN	1812208
CAS DataBase Reference	35356-70-8(CAS DataBase Reference)

Safety information for Methyl 2-acetamidoacrylate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.