Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
- CAS NO.:89937-77-9
- Empirical Formula: C7H7NO3
- Molecular Weight: 153.14
- MDL number: MFCD09258780
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate?
The Uses of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is an ester derivative, mainly used as a pharmaceutical intermediate.
Synthesis
The synthesis method of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is as follows: Dissolve 10 g (0.066 mol) of m-nitrobenzaldehyde and 11 g (0.067 mol) of ethyl chloroacetate in 60 ml of benzene, and add 1 ml of piperidine. 1 ml of glacial acetic acid, heated in a water bath, and the water generated in the reaction was continuously removed with a Dean-start water separator. After refluxing for 3h, the benzene was evaporated, 20ml of ether was added to the residue, frozen, crystallized, suction filtered, and dried to give 16.2g of methyl 2-hydroxypyridine-4-carboxylate, yield 82%, mp 92 -96°C.
Properties of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
Melting point: | 211-212 °C |
Boiling point: | 342.4±42.0 °C(Predicted) |
Density | 1.263±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
pka | 11.02±0.10(Predicted) |
color | White to off-white |
Safety information for Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
New Products
2,2-diethoxyethanethioamide Tubulysin F Tubulysin E Tubulysin A 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 4-(Benzyloxy)-3-bromophenylacetic Acid 4,4-DIFLUOROPIPERIDINE 3-Aminocyclobutanone hydrochloride Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Fuel shell Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
methyl 2-oxo-1,2-dihydropyridine-3-carboxylate
ETHYL 3-CYANO-2-HYDROXY-6-METHYLISONICOTINATE
1,2-Dihydro-1-methyl-3-nitro-2-oxo-4-pyridinecarboxylic acid methyl ester
ETHYL 1,2-DIHYDRO-6-METHYL-3-NITRO-2-OXO-4-PYRIDEINCARBOXYLATE
ISONICOTINIC ACID, 3-CYANO-1,2-DIHYDRO-2-OXO-, ETHYL ESTER
SPECS AJ-333/25022077
AURORA KA-5535
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
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