Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate

CAS NO.：89937-77-9
Empirical Formula: C7H7NO3
Molecular Weight: 153.14
MDL number: MFCD09258780
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate?

The Uses of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate

Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is an ester derivative, mainly used as a pharmaceutical intermediate.

Synthesis

The synthesis method of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is as follows: Dissolve 10 g (0.066 mol) of m-nitrobenzaldehyde and 11 g (0.067 mol) of ethyl chloroacetate in 60 ml of benzene, and add 1 ml of piperidine. 1 ml of glacial acetic acid, heated in a water bath, and the water generated in the reaction was continuously removed with a Dean-start water separator. After refluxing for 3h, the benzene was evaporated, 20ml of ether was added to the residue, frozen, crystallized, suction filtered, and dried to give 16.2g of methyl 2-hydroxypyridine-4-carboxylate, yield 82%, mp 92 -96°C.

Properties of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate

Melting point:	211-212 °C
Boiling point:	342.4±42.0 °C(Predicted)
Density	1.263±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	11.02±0.10(Predicted)
color	White to off-white

Safety information for Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.