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HomeProduct name listMETHOXAMINE HYDROCHLORIDE

METHOXAMINE HYDROCHLORIDE

Synonym(s):α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride

  • CAS NO.:61-16-5
  • Empirical Formula: C11H18ClNO3
  • Molecular Weight: 247.72
  • MDL number: MFCD00058607
  • EINECS: 200-499-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:55:00
METHOXAMINE HYDROCHLORIDE Structural

What is METHOXAMINE HYDROCHLORIDE?

Originator

Vasoxyl ,Burroughs-Wellcome,US,1949

The Uses of METHOXAMINE HYDROCHLORIDE

Antihypotensive;Alpha adrenergic agonist

The Uses of METHOXAMINE HYDROCHLORIDE

anti-fungal

The Uses of METHOXAMINE HYDROCHLORIDE

Methoxamine is an α1-adrenergic receptor agonist. It induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure.

What are the applications of Application

Methoxamine hydrochloride is An agonist to α-1-adrenoceptors

Definition

ChEBI: Methoxamine hydrochloride is a dimethoxybenzene.

Manufacturing Process

2,5-Dimethoxypropiophenone is treated in absolute ether with methyl nitrite and hydrogen chloride. The hydrochloride of 2,5-dimethoxy-αisonitrosopropiophenone crystallizes out of the solution. It is removed, the base is liberated and crystallized from benzene-heptane forming yellow leaflets that melt at about 97° to 98°C. This isonitrosoketone is dissolved in absolute alcohol containing an excess of hydrogen chloride and is hydrogenated with palladized charcoal, yielding β-(2,5-dimethoxyphenyl)-βketoisopropylamine hydrochloride, a salt that melts at about 176°C with decomposition.
12.3 g (1/20 mol) of β-(2,5-dimethoxyphenyl)-β-ketoisopropylamine hydrochloride (MP 176°C) is dissolved in 50 cc of water and hydrogenated with platinum oxide platinum black in the customary Adams-Burgess Parr apparatus. About 1/20 mol of hydrogen is absorbed, after which the solution is filtered off from the catalyst, evaporated to dryness in vacuo and recrystallized from absolute alcohol, absolute ether being added to decrease solubility. The hydrochloride is thus obtained in substantially theoretical yield. It crystallizes in plates and melts at 215°C.

Therapeutic Function

Hypertensive

Biochem/physiol Actions

α1-adrenoceptor agonist.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. An FDA proprietary drug. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Properties of METHOXAMINE HYDROCHLORIDE

Melting point: 215℃
refractive index  1.5204
storage temp.  2-8°C
solubility  DMSO (Slightly), Methanol (Slightly)
pka 9.2(at 25℃)
form  Solid
color  White to off-white
CAS DataBase Reference 61-16-5(CAS DataBase Reference)

Safety information for METHOXAMINE HYDROCHLORIDE

Computed Descriptors for METHOXAMINE HYDROCHLORIDE

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