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HomeProduct name listMERBROMIN

MERBROMIN

Synonym(s):2′,7′-Dibromo-5′-(hydroxymercurio)fluorescein disodium salt;Merbromin;Mercurochrome

  • CAS NO.:129-16-8
  • Empirical Formula: C20H11Br2HgNaO6
  • Molecular Weight: 730.69
  • MDL number: MFCD00013081
  • EINECS: 204-933-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-07 21:39:59
MERBROMIN Structural

What is MERBROMIN?

Chemical properties

dark green solid

Originator

Mercurin,Monik

The Uses of MERBROMIN

anthelmintic

The Uses of MERBROMIN

Antiseptic and applied topically

Definition

ChEBI: An organic sodium salt that is 2,7-dibromo-4-hydroxymercurifluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.

Manufacturing Process

49 g 2,7-dibromofluorescein are dissolved in a solution of 8 g of sodium hydroxide in 50 ml of water, and diluted to 200 ml 12.5 ml of glacial acetic acid are added to this solution with stirring. A homogeneous pasty precipitate results with vigorously stirring. A filtered solution of about 22.5 g of mercuric oxide in 25 ml of glacial acid and 50 ml water, diluted after solution to 100 ml, is then added to the suspended precipitate, and the whole diluted to about 500 ml. The mixture is boiled until a small portion of filtered solution gives no test for mercury when treated with ammonium sulfide, the approximate time required for this operation being about 4.5-6 hours. As the boiling continues the precipitate become darker in color and more granular. It is washed, preferably by centrifuging, to remove acetic acid and sodium acetate, and dried at about 110°C. By close adherence to above conditions an almost quantitative yield may be secured. The product may be regarded as consisting essentially of 2,7-dibromo-4-hydroxymercuryfluorescein, resulting from substantially complete hydrolysis of an acetoxy-mercury compound, which probably formed as an intermediate. It is red powder, which is insoluble in the usual solvents but dissolves in two equivalents of sodium hydroxide yielding a deep cherry-red solution. The solution has the tendency to decomposition on long standing.

Therapeutic Function

Antiseptic

Hazard

Toxic by ingestion.

Flammability and Explosibility

Not classified

Safety Profile

Poison by intravenous and subcutaneous routes. Mutation data reported. Relatively nonirritating and nontoxic to damaged skin or tissue. A topical antiseptic. An FDA over-the-counter drug. When heated to decomposition it emits very toxic fumes including fumes of Na2O, Br-, and Hg. See also MERCURY COMPOUNDS, ORGANIC.

Purification Methods

The Na salt is dissolved in the minimum volume of H2O, or the free acid suspended in H2O and dilute NaOH is added to cause it to dissolve, filter and acidify it with dilute HCl. Collect the precipitate, wash it with H2O by centrifugation and dry it in a vacuum. The di Na salt can be purified by dissolving it in the minimum volume of H2O and is precipitated by adding EtOH, filter, wash it with EtOH or Me2CO and dry it in a vacuum. Its solubility in 95% EtOH is 2% and in MeOH it is 16%. [White J Am Chem Soc 42 2355 1920.]

Properties of MERBROMIN

Melting point: ≥300 °C
storage temp.  Poison room
solubility  Water : ≥ 50 mg/mL (66.43 mM);DMSO : 6.67 mg/mL (8.86 mM)
form  crystalline
color  green
Odor Odorless
PH Range 8.5 - 9
Water Solubility  2.561g/L at 25℃
Merck  13,5892
Stability: Stable. Incompatible with strong oxidizing agents, strong acids.
CAS DataBase Reference 129-16-8(CAS DataBase Reference)
EPA Substance Registry System Mercury, (2',7'-dibromo-3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-4'-yl)hydroxy-, disodium salt (129-16-8)

Safety information for MERBROMIN

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H373:Specific target organ toxicity, repeated exposure
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P262:Do not get in eyes, on skin, or on clothing.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P314:Get medical advice/attention if you feel unwell.

Computed Descriptors for MERBROMIN

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